Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.12202/1050
Title: | Characterization and physiological function of RGEF-1b, a calcium and diacylglycerol-regulated guanine nucleotide exchange factor |
Authors: | Chen, Lu |
Keywords: | Cellular biology. |
Issue Date: | 2009 |
Publisher: | ProQuest Dissertations & Theses |
Citation: | Source: Dissertation Abstracts International, Volume: 70-04, Section: B, page: 2012.;Advisors: Charles Rubin. |
Abstract: | RasGRPs catalyze exchange of GTP for GDP on p21 Ras and Rap1 proteins. Conserved C1 and EF hand domains in RasGRP polypeptides suggest catalytic activity may be controlled by diacylglycerol (DAG) and Ca2+, respectively. RasGRPs are expressed in platelets, B, T and mast cells and neurons. Functions have been assigned to RasGRPs in blood cells, but their roles in neurons are unknown.;I investigated regulation, functions and effectors of RGEF-1b (a RasGRP homolog) in C. elegans neurons. A single gene rgef-1, encodes RGEF and RGEF-1b via alternative splicing. The rgef-1 promoter is active in all neurons and >95% of gene transcripts encode RGEF-1b (620 amino acids). RGEF-1 deficient animals have impaired chemotaxis to odorants detected by AWC (2-butanone, benzaldehyde). An rgef-1 |
URI: | https://ezproxy.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:3357458 https://hdl.handle.net/20.500.12202/1050 |
Appears in Collections: | Albert Einstein College of Medicine: Doctoral Dissertations |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.