Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12202/1405
Title: A causative link between inner ear defects and long-term striatal dysfunction
Authors: Antoine, Michelle W.
Keywords: Behavioral sciences.
Neurosciences.
Behavioral psychology.
Issue Date: 2013
Publisher: ProQuest Dissertations & Theses
Citation: Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.;Advisors: Jean M. Hebert.
Abstract: Psychiatric disorders frequently occur with inner ear dysfunction. Although socioenvironmental variables have been proposed as risk-factors, it is unclear, whether inner ear dysfunction can directly change brain function to promote abnormal behavior. Using Slc12a2 mutant mice, a model of inner ear dysfunction and Slc12a2 tissue-specific knockouts, we show that inner ear dysfunction induces a dopamine dependent increase in locomotor and repetitive motor activity by altering ventral neuro-striatal levels of pERK1/2, an intracellular mediator of striatal dopamine and glutamate signaling. Administration of the pERK1/2 inhibitor SL327 to the nucleus accumbens of the ventral striatum reverses this phenotype. Hence this study, in revealing a biological basis for the comorbidity of abnormal behavior and inner ear dysfunction, suggests that sensory impairment can contribute to psychiatric disorders traditionally considered exclusively of cerebral origin.
URI: https://ezproxy.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:3570194
https://hdl.handle.net/20.500.12202/1405
Appears in Collections:Ferkauf Graduate School of Psychology: Doctoral Dissertations

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