Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.12202/1405
Title: | A causative link between inner ear defects and long-term striatal dysfunction |
Authors: | Antoine, Michelle W. |
Keywords: | Behavioral sciences. Neurosciences. Behavioral psychology. |
Issue Date: | 2013 |
Publisher: | ProQuest Dissertations & Theses |
Citation: | Source: Dissertation Abstracts International, Volume: 74-09(E), Section: B.;Advisors: Jean M. Hebert. |
Abstract: | Psychiatric disorders frequently occur with inner ear dysfunction. Although socioenvironmental variables have been proposed as risk-factors, it is unclear, whether inner ear dysfunction can directly change brain function to promote abnormal behavior. Using Slc12a2 mutant mice, a model of inner ear dysfunction and Slc12a2 tissue-specific knockouts, we show that inner ear dysfunction induces a dopamine dependent increase in locomotor and repetitive motor activity by altering ventral neuro-striatal levels of pERK1/2, an intracellular mediator of striatal dopamine and glutamate signaling. Administration of the pERK1/2 inhibitor SL327 to the nucleus accumbens of the ventral striatum reverses this phenotype. Hence this study, in revealing a biological basis for the comorbidity of abnormal behavior and inner ear dysfunction, suggests that sensory impairment can contribute to psychiatric disorders traditionally considered exclusively of cerebral origin. |
URI: | https://ezproxy.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:3570194 https://hdl.handle.net/20.500.12202/1405 |
Appears in Collections: | Ferkauf Graduate School of Psychology: Doctoral Dissertations |
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