Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12202/3331
Title: Molecular cloning and characterization of human glutathione S-transferases
Authors: Campbell, Eggerton Anthony
Keywords: Biochemistry.
Issue Date: 1990
Publisher: ProQuest Dissertations & Theses
Citation: Source: Dissertation Abstracts International, Volume: 51-08, Section: B, page: 3817.;Advisors: Irving Listowsky.
Abstract: Glutathione S-Transferases (GSTs) are abundant proteins that function principally in detoxification, intracellular binding and transport. Mammalian cytosolic GSTs may be subdivided into three different classes designated as {dollar}\alpha{dollar}, {dollar}\mu{dollar} and {dollar}\pi{dollar}. The {dollar}\mu{dollar}-class GSTs have higher activity with selective groups of chemical carcinogens and toxins, such as benzo(a)-pyrene-4,5-oxide and styrene 7-8-oxide, as substrates. As a result of a gene deletion, approximately 50% of the human population is missing the hepatic {dollar}\mu{dollar}-class GST. This half of the population may be more susceptible to chemical carcinogens and drug toxicity. Our objectives were: (i) to determine effects of this gene deletion in extrahepatic tissues such as brain and testis where ordinarily the {dollar}\mu{dollar}-class GSTs are major forms; (ii) to determine if the hepatic {dollar}\mu{dollar}-class GST form is also present in other tissues; and (iii) to apply molecular cloning methods for characterization of multiple GSTs in extrahepatic tissue and the genes that encode them. (Abstract shortened with permission of author.).
URI: https://ezproxy.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:9030770
https://hdl.handle.net/20.500.12202/3331
Appears in Collections:Albert Einstein College of Medicine: Doctoral Dissertations

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