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dc.contributor.authorKnowles, Brenda Brodeur
dc.date.accessioned2018-07-12T18:36:28Z
dc.date.available2018-07-12T18:36:28Z
dc.date.issued1992
dc.identifier.citationSource: Dissertation Abstracts International, Volume: 53-01, Section: B, page: 7200.;Advisors: R. Scott Hawley.
dc.identifier.urihttp://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:9216668
dc.identifier.urihttps://hdl.handle.net/20.500.12202/3418
dc.description.abstractThe nod, no distributive disjunction and ncd, non-claret disjunctional are female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of chromosome nondisjunction at meiosis I and both loci have been shown to encode kinesin-like proteins. Unlike the ncd mutation, which affects all chromosome pairs, nod only affects disjunction of nonexchange chromosomes. This report describes experiments that seek, through second-site noncomplementation analysis and in situ hybridization experiments to define the relationship between these genes.;Although both the nod and ncd mutations are fully recessive, females doubly heterozygous for nod and ncd mutations were found to have levels of X and fourth chromosome nondisjunction 6-to-35 fold above those observed in control females. We infer that ncd is a dominant enhancer of nod. In situ hybridization data reveal that these transcripts have largely overlapping expression patterns during oogenesis. We propose that the relationship between the nod and ncd kinesin-like proteins is not one of direct structural interaction, but rather one defined by the temporal nature of the meiotic process.
dc.publisherProQuest Dissertations & Theses
dc.subjectGenetics.
dc.subjectMolecular biology.
dc.titleA genetic and molecular analysis of two Drosophila meiotic mutants encoding kinesin-like proteins
dc.typeDissertation


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