Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12202/4090
Title: Regulation of Cyclin-Dependent Kinase 1 (CDC2) by SUMO
Authors: Sonenberg, Helene
Keywords: Cyclin-dependent kinases.
Phosphorylation.
Germ cells.
Cell cycle.
Cellular signal transduction.
Cellular control mechanisms.
Protein kinases.
Issue Date: Aug-2015
Publisher: Stern College for Women
Abstract: Sumoylation and phosphorylation are post-translational modifications that have been identified as important regulatory events that are implicated in several cellular processes. The aim of this research was to study a cross-talk between sumoylation and phosphorylation during the cell cycle, specifically by analyzing the activity of CDC2 upon inhibition of sumoylation with a sumoylation inhibitor, ginkgolic acid (GA), and physiological/low levels of H2O2. The activity of CDC2 was assessed using antibodies against an inactive and total isoform of the protein. Our data suggest that inhibition of sumoylation activates CDC2 and, therefore, its activity is inhibited by sumoylation. Further studies will address the mechanism of the inhibition.
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URI: https://hdl.handle.net/20.500.12202/4090
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Appears in Collections:S. Daniel Abraham Honors Student Theses

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