Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12202/4141
Title: New genes often acquire male-specific functions but rarely become essential in Drosophila.
Authors: Steinhauer, Josefa
Kondo, Shu
Vedanayagam, Jeffrey
Mohammed, Jaaved
Eizadshenass, Sogol
Kan, Lijuan
Pang, Nan
Aradhya, Rajaguru
Siepel, Adam
Lai, Eric C.
0000-0002-0960-5271
Keywords: Drosophila
gene evolution
spermatogenesis
testis
Issue Date: 15-Sep-2017
Publisher: Cold Spring Harbor Laboratory Press
Citation: Steinhauer, J., Kondo, S., Mohammed, J., Eizadshenass, S., Kan, L., Pang, N. Aradhya, R., Siepel, A., Lai, E.C. (2017) New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes and Development 31(18): 1841-1846.
Abstract: Relatively little is known about the in vivo functions of newly emerging genes, especially in metazoans. Although prior RNAi studies reported prevalent lethality among young gene knockdowns, our phylogenomic analyses reveal that young Drosophila genes are frequently restricted to the nonessential male reproductive system. We performed large-scale CRISPR/Cas9 mutagenesis of “conserved, essential” and “young, RNAi-lethal” genes and broadly confirmed the lethality of the former but the viability of the latter. Nevertheless, certain young gene mutants exhibit defective spermatogenesis and/or male sterility. Moreover, we detected widespread signatures of positive selection on young male-biased genes. Thus, young genes have a preferential impact on male reproductive system function.
Description: Received June 11, 2017. Accepted September 12, 2017. © 2017 Kondo et al.; Published by Cold Spring Harbor Laboratory Press This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
URI: http://www.genesdev.org/cgi/doi/10.1101/gad.303131.117.
https://hdl.handle.net/20.500.12202/4141
ISSN: 0890-9369
Appears in Collections:Yeshiva College: Faculty Publications

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