Pancreatic ductal adenocarcinoma (PDAC) is the most common neoplasm of the
pancreas. Despite its low frequency of 6-12 people per 100,000 per year, it is the fourth leading
cause of cancer death in the United States. This high mortality rate can be attributed to a lack of
early detection methods and effective treatments. Chronic pancreatitis has been shown to be a
risk factor for pancreatic cancer and is characterized by fibro-inflammatory changes of the
pancreatic tissue. This study sought to create a mouse model that mimics the symptoms of
chronic pancreatitis seen in humans associated with PDAC. A suitable model will display a
transient state from acinar-ductal meta-plasia (ADM) to PanINs without progressing to cancer.
Such a model would provide the chance to examine the precursor to PDAC and potentially pave
the way towards designing new treatment options.
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