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dc.contributor.authorBrander, Tehilla
dc.date.accessioned2018-11-12T21:35:30Z
dc.date.available2018-11-12T21:35:30Z
dc.date.issued2014-05
dc.identifier.urihttps://hdl.handle.net/20.500.12202/4241
dc.descriptionThe file is restricted for YU community access only.
dc.description.abstractAccording to the National Institute of Health, half of women and a quarter of men will break a bone due to osteoporosis, a disease categorized by low bone density. Bone density and strength are regulated by two types of cells, osteoclasts, which dissolve bone, and osteoblasts which build bone. If the balance between osteoclasts and osteoblasts is disturbed, a diseased state will occur. While osteoporosis is caused by a relative increase in osteoclast activity, osteopetrosis, a genetic disease categorized by extremely high bone density, is caused by a decrease in osteoclast activity. It has been suggested that environmental factors may influence osteoclast and osteoblast function. Through the use of a variety of chemical compounds, one can endeavor to manipulate the transcription or post-transcriptional modification of RNA transcripts critical to the functioning of osteoclasts, thereby compromising osteoclast function and enhancing bone density. HL-60 and THP1 cell lines were treated with various nutraceuticals and screened for possible transcriptional/posttranscriptional changes in gene-encoded transcripts critical to osteoclast function. Both RTPCR and qRT-PCR analysis has demonstrated that treatment of cells with extracts generated from Gymnema Sylvestre results in a post-transcriptional modification that results in the generation of an alternatively spliced transcript form of the transcript encoded by the RANK gene. As mutations in the RANK gene that compromise the functionality of this gene product have been demonstrated to cause osteopetrosis, through its effect on osteoclast differentiation and survival, it is believed that Gymnema Sylvestre extract may be able to compromise osteoclast function and be used as a treatment for osteoporosis.en_US
dc.description.sponsorshipS. Daniel Abraham Honors Programen_US
dc.language.isoen_USen_US
dc.publisherStern College for Womenen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectAsclepiadaceae --Therapeutic use.en_US
dc.subjectRNA.en_US
dc.subjectOsteoporosis --Treatment.en_US
dc.subjectOsteoporosis --Prevention.en_US
dc.subjectHerbs --Therapeutic use.en_US
dc.subjectMateria medica, Vegetable.en_US
dc.titleEffects of Gymnema Sylvestre on the post-transcriptional processing of the RANK -encoded RNA: A Possible Treatment for Osteoporosisen_US
dc.typeThesisen_US


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  • Honors Student Theses [208]
    Senior honors theses sponsored by the S. Daniel Abraham Honors Program of Stern College for Women

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States