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https://hdl.handle.net/20.500.12202/505
Title: | The role of heparan sulfates in the development and function of the nervous system |
Authors: | Lazaro-Pena, Maria I. |
Keywords: | Genetics. Neurosciences. |
Issue Date: | 2017 |
Publisher: | ProQuest Dissertations & Theses |
Citation: | Source: Dissertation Abstracts International, Volume: 79-09(E), Section: B.;Advisors: Scott W. Emmons. |
Abstract: | The nervous system regulates complex behaviors through a network of neurons interconnected by synapses. However, how these are genetically predetermined is still unclear. Male mating is the most complex behavior in C. elegans . It is composed of sequential steps that are governed by more than 3,000 chemical connections. In this work, I show that heparan sulfate (HS) play a role in the formation and function of the male neural network. HS modification enzymes and HS proteoglycans (HSPG) were required for the anteroposterior and dorsoventral axonal migration of male-specific sensory neurons. Specifically, dorsoventral axonal migration of RnB was achieved through regulation of netrin signaling. Furthermore, cell-autonomous and non- autonomous 3-O sulfation by the HS modification enzyme HST-3.1, localized to the HSPG glypicans LON-2 and GPN-1, was specifically required for response to hermaphrodite contact during mating. Loss of 3-O sulfation in the postsynaptic cell, resulted in accumulation of mCherry |
URI: | https://ezproxy.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10835809 https://hdl.handle.net/20.500.12202/505 |
Appears in Collections: | Albert Einstein College of Medicine: Doctoral Dissertations |
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