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dc.contributor.authorLazaro-Pena, Maria I.
dc.date.accessioned2018-07-12T17:02:02Z
dc.date.available2018-07-12T17:02:02Z
dc.date.issued2017
dc.identifier.citationSource: Dissertation Abstracts International, Volume: 79-09(E), Section: B.;Advisors: Scott W. Emmons.
dc.identifier.urihttp://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:10835809
dc.identifier.urihttps://hdl.handle.net/20.500.12202/505
dc.description.abstractThe nervous system regulates complex behaviors through a network of neurons interconnected by synapses. However, how these are genetically predetermined is still unclear. Male mating is the most complex behavior in C. elegans . It is composed of sequential steps that are governed by more than 3,000 chemical connections. In this work, I show that heparan sulfate (HS) play a role in the formation and function of the male neural network. HS modification enzymes and HS proteoglycans (HSPG) were required for the anteroposterior and dorsoventral axonal migration of male-specific sensory neurons. Specifically, dorsoventral axonal migration of RnB was achieved through regulation of netrin signaling. Furthermore, cell-autonomous and non- autonomous 3-O sulfation by the HS modification enzyme HST-3.1, localized to the HSPG glypicans LON-2 and GPN-1, was specifically required for response to hermaphrodite contact during mating. Loss of 3-O sulfation in the postsynaptic cell, resulted in accumulation of mCherry
dc.publisherProQuest Dissertations & Theses
dc.subjectGenetics.
dc.subjectNeurosciences.
dc.titleThe role of heparan sulfates in the development and function of the nervous system
dc.typeDissertation


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