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dc.contributor.authorAntoine, Michelle W.
dc.date.accessioned2018-07-12T17:39:45Z
dc.date.available2018-07-12T17:39:45Z
dc.date.issued2013
dc.identifier.citationSource: Dissertation Abstracts International, Volume: 74-09(E), Section: B.;Advisors: Jean M. Hebert.
dc.identifier.urihttps://yulib002.mc.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:3570194
dc.identifier.urihttps://hdl.handle.net/20.500.12202/1405
dc.description.abstractPsychiatric disorders frequently occur with inner ear dysfunction. Although socioenvironmental variables have been proposed as risk-factors, it is unclear, whether inner ear dysfunction can directly change brain function to promote abnormal behavior. Using Slc12a2 mutant mice, a model of inner ear dysfunction and Slc12a2 tissue-specific knockouts, we show that inner ear dysfunction induces a dopamine dependent increase in locomotor and repetitive motor activity by altering ventral neuro-striatal levels of pERK1/2, an intracellular mediator of striatal dopamine and glutamate signaling. Administration of the pERK1/2 inhibitor SL327 to the nucleus accumbens of the ventral striatum reverses this phenotype. Hence this study, in revealing a biological basis for the comorbidity of abnormal behavior and inner ear dysfunction, suggests that sensory impairment can contribute to psychiatric disorders traditionally considered exclusively of cerebral origin.
dc.publisherProQuest Dissertations & Theses
dc.subjectBehavioral sciences.
dc.subjectNeurosciences.
dc.subjectBehavioral psychology.
dc.titleA causative link between inner ear defects and long-term striatal dysfunction
dc.typeDissertation


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