Show simple item record

dc.contributor.authorKAGAN, BRUCE LAURENCE
dc.date.accessioned2018-07-12T18:11:07Z
dc.date.available2018-07-12T18:11:07Z
dc.date.issued1982
dc.identifier.citationSource: Dissertation Abstracts International, Volume: 43-02, Section: B, page: 3490.
dc.identifier.urihttps://yulib002.mc.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:8215449
dc.identifier.urihttps://hdl.handle.net/20.500.12202/2766
dc.description.abstractThe bactericidal action of colicins K, E1, Ia and other functionally related colicins involves disruption of active transport and leakage of ions from the cell. I show that a single colicin molecule can form a voltage-dependent, relatively non-selective, ion permeable channel of a few picosiemens conductance in a planar phospholipid bilayer membrane. I suggest that the in vivo physiological effects of these colicins result from their ability to form ion-permeable channels in the bacterial inner membrane.;The voltage-dependent behavior of at least one colicin appears to be well described by a simple two state model based on the Boltzmann relation. The striking resemblance between the electrophysiology of the colicins and that of the voltage-dependent channels of nerve and muscle make the colicins an attractive model system for studying the molecular basis of ion channel gating.
dc.publisherProQuest Dissertations & Theses
dc.subjectAnimal Physiology.
dc.titleVOLTAGE-DEPENDENT CHANNELS FORMED BY COLICINS
dc.typeDissertation


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record