• Login as Editor
    View Item 
    •   Yeshiva Academic Institutional Repository
    • Albert Einstein College of Medicine (AECOM)
    • Albert Einstein College of Medicine: Doctoral Dissertations
    • View Item
    •   Yeshiva Academic Institutional Repository
    • Albert Einstein College of Medicine (AECOM)
    • Albert Einstein College of Medicine: Doctoral Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Studies on the histone genes of Caenorhabditis elegans

    Thumbnail
    Date
    1988
    Author
    Sanicola, Michele
    Metadata
    Show full item record
    Abstract
    The aim of this project is to study the temporal and tissue-specific regulation of the C. elegans histone genes. As a first step towards this goal, the organization, structure, and expression of these genes has been characterized (Roberts et al., 1987; this study). C. elegans has approximately 10-12 dispersed clusters of core histone genes (H2A, H2B, H3, H4). Several histone clusters have been mapped using restriction fragment polymorphisms associated with histone gene clusters as markers in genetic crosses. No single major histone locus was detected. The core histone transcripts have been identified and their temporal pattern of expression analyzed.;An unusual feature of the C. elegans histone gene family is that the histone H1 sequences are located outside of the clusters of core genes. One member of the C. elegans H1 gene family has been cloned and characterized. It has several atypical features. The gene contains an intervening sequence and the transcript is polyadenylated. Another member of the H1 gene family appears to encode a sperm-specific H1 transcript. The identification of this sperm-specific transcript will provide a means for us to study the mechanisms of tissue-specific gene expression.
    Permanent Link(s)
    https://yulib002.mc.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:8807257
    https://hdl.handle.net/20.500.12202/3183
    Collections
    • Albert Einstein College of Medicine: Doctoral Dissertations [1674]

    Yeshiva University Libraries copyright © 2021  DuraSpace
    YAIR Self-Deposit | YAIR User's Guide | Take Down Policy | Contact Us
    Yeshiva University
     

     

    Browse

    AllCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login as Editor

    Statistics

    View Usage Statistics

    Yeshiva University Libraries copyright © 2021  DuraSpace
    YAIR Self-Deposit | YAIR User's Guide | Take Down Policy | Contact Us
    Yeshiva University