• Login as Editor
    View Item 
    •   Yeshiva Academic Institutional Repository
    • Albert Einstein College of Medicine (AECOM)
    • Albert Einstein College of Medicine: Doctoral Dissertations
    • View Item
    •   Yeshiva Academic Institutional Repository
    • Albert Einstein College of Medicine (AECOM)
    • Albert Einstein College of Medicine: Doctoral Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Genetic analysis of a mutation defective in chromosome partner choice

    Thumbnail

    Date
    1989
    Author
    Zitron, Anne Elizabeth
    Metadata
    Show full item record
    Share
    Abstract
    This report describes the isolation and characterization of Aberrant X segregation (Axs), a dominant female-specific meiotic mutation in Drosophila melanogaster. Axs has little or no effect on the frequency or distribution of exchange, or on the disjunction of exchange bivalents. Nonexchange X chromosomes nondisjoin at high frequencies in Axs females which is shown to result from an Axs-induced defect in distributive segregation. Fourth chromosome nondisjunction in Axs is observed only in the presence of high frequencies of nonexchange X chromosomes and is argued to be the result of improper X-4 associations within the distributive system. Indeed, in XX females bearing a compound 4 chromosome, the frequency of nonhomologous disjunction of the X chromosomes from the compound 4 accounts for at least 80% of the total X nondisjunction observed. Axs diminishes or ablates the capacity of nonexchange X chromosomes to form trivalents in females bearing either a Y or a small free duplication for the X, and also impairs compound X from Y segregation. The effect of Axs on these segregations parallels the defects observed for homologous nonexchange X segregation. In addition to its dramatic effects on X chromosome disjunction, Axs exerts a similar effect on the segregation of the major autosomes. It is concluded that Axs defines a locus required for proper homolog disjunction within the distributive system.
    Permanent Link(s)
    https://ezproxy.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:8917452
    https://hdl.handle.net/20.500.12202/3254
    Citation
    Source: Dissertation Abstracts International, Volume: 50-04, Section: B, page: 1239.;Advisors: R. Scott Hawley.
    *This is constructed from limited available data and may be imprecise.
    Collections
    • Albert Einstein College of Medicine: Doctoral Dissertations [1674]

    Yeshiva University Libraries copyright © 2021  DuraSpace
    YAIR Self-Deposit | YAIR User's Guide | Take Down Policy | Contact Us
    Yeshiva University
     

     

    Browse

    AllCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login as Editor

    Statistics

    View Usage Statistics

    Yeshiva University Libraries copyright © 2021  DuraSpace
    YAIR Self-Deposit | YAIR User's Guide | Take Down Policy | Contact Us
    Yeshiva University