Obstructive sleep apnea, a sleep disorder known to cause airway blockage and
inability to breathe during the night, has been associated with a decrease in Gammaaminobutyric
acid (GABA) measured using msing proton magnetic resonance spectroscopy
H MRS) in the prefrontal cortex of the human brain, a region associated with executive
function. This study aimed to obtain a fuller understanding of the mechanisms behind the
human finding by investigating GABA content in the brains of hypoxic mice. Characterized
by deprivation of sufficient oxygen supply, hypoxia is one of the major symptoms in
obstructive sleep apnea. In fact, chronic intermittent hypoxic mouse models are often used to
study aspects of obstructive sleep apnea.
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