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dc.contributor.authorKramer-Rex, Melissa
dc.date.accessioned2018-11-08T20:31:32Z
dc.date.available2018-11-08T20:31:32Z
dc.date.issued2015-12
dc.identifier.urihttps://hdl.handle.net/20.500.12202/4165
dc.identifier.urihttps://yulib002.mc.yu.edu/login?url=https://repository.yu.edu/handle/20.500.12202/4165
dc.descriptionThe file is restricted for YU community access only.
dc.description.abstractThe growing use of oral contraceptives and hormone therapeutics gives rise to the concern that estrogenic and progestogenic compounds are present in wastewater at concentrations that may affect aquatic species. This study showed that wastewater effluent produced by the Charleston Water System facility at Plum Island, when concentrated 100 times, contains endocrine active compounds that activate the human nuclear estrogen and progesterone receptors in an in vitro transactivation assay system. This may provide a mechanism for the alterations in secondary sex characteristics that have been reported in fish exposed to wastewater effluent from other locations. Some synthetic hormones have also been found to be bioaccumulated in teleost fishes. There is, therefore, potential for humans to be exposed to these endocrine active compounds through consumption of these fishes. The current study evaluated the effects of neonatal exposure to progestogens on the regulation of reproductive development by estradiol (E2) stimulation in adults, using mice as a model. Quantitative PCR analysis of target genes from mice treated with the synthetic progesterone 17α-hydroxyprogesterone caproate (17PC) as neonates suggested that developmental exposure to progestogens might decrease sensitivity to E2 at the uterine transcriptome level, and showed patterns similar to microarray data that revealed that perinatal exposure to 17PC suppressed uterine E2 sensitivity in the adult. These data indicate a need for further exploration of the subject.en_US
dc.description.sponsorshipS. Daniel Abraham Honors Programen_US
dc.language.isoen_USen_US
dc.publisherStern College for Womenen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectWildlife as food --Contamination --United States.en_US
dc.subjectFishes --Effect of pollution on --United States.en_US
dc.subjectEndocrine disrupting chemicals in water --Environmental aspects --United States.en_US
dc.subjectReproductive toxicology --Environmental aspects --United States.en_US
dc.subjectHuman reproduction --Effect of chemicals on --Environmental aspects --United States.en_US
dc.subjectWater --Pollution --Environmental aspects --United States.en_US
dc.subjectWater-supply --Health aspects --United States.en_US
dc.subjectOral contraceptives --Environmental aspects --United States.en_US
dc.subjectHormone therapy --Environmental aspects --United States.en_US
dc.subjectEndocrine toxicology --Environmental aspects --United States.en_US
dc.subjectEstrogen --Environmental aspects --United States.en_US
dc.subjectProgestational hormones --Environmental aspects --United States.en_US
dc.titleDrugged Wildlife: The Potential Impacts of Environmental Endocrine Disruptors on Reproductive Developmenten_US
dc.typeThesisen_US


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States