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dc.contributor.authorAkhavan, Nathan
dc.descriptionThe file is restricted for YU community access only.
dc.description.abstractPancreatic ductal adenocarcinoma (PDAC) is the most common neoplasm of the pancreas. Despite its low frequency of 6-12 people per 100,000 per year, it is the fourth leading cause of cancer death in the United States. This high mortality rate can be attributed to a lack of early detection methods and effective treatments. Chronic pancreatitis has been shown to be a risk factor for pancreatic cancer and is characterized by fibro-inflammatory changes of the pancreatic tissue. This study sought to create a mouse model that mimics the symptoms of chronic pancreatitis seen in humans associated with PDAC. A suitable model will display a transient state from acinar-ductal meta-plasia (ADM) to PanINs without progressing to cancer. Such a model would provide the chance to examine the precursor to PDAC and potentially pave the way towards designing new treatment options.en_US
dc.description.sponsorshipJay and Jeanie Schottenstein Honors Programen_US
dc.publisherYeshiva Collegeen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.subjectPancreatitis --Research.en_US
dc.subjectPancreas --Cancer --Research.en_US
dc.titleInvestigating the Roles of SMAD4 and TGF-α in Promoting Metaplasia and Pancreatitisen_US

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States