dc.contributor.author | Akhavan, Nathan | |
dc.date.accessioned | 2018-11-08T21:02:24Z | |
dc.date.available | 2018-11-08T21:02:24Z | |
dc.date.issued | 2016-01 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12202/4177 | |
dc.identifier.uri | https://yulib002.mc.yu.edu/login?url=https://repository.yu.edu/handle/20.500.12202/4177 | |
dc.description | The file is restricted for YU community access only. | |
dc.description.abstract | Pancreatic ductal adenocarcinoma (PDAC) is the most common neoplasm of the
pancreas. Despite its low frequency of 6-12 people per 100,000 per year, it is the fourth leading
cause of cancer death in the United States. This high mortality rate can be attributed to a lack of
early detection methods and effective treatments. Chronic pancreatitis has been shown to be a
risk factor for pancreatic cancer and is characterized by fibro-inflammatory changes of the
pancreatic tissue. This study sought to create a mouse model that mimics the symptoms of
chronic pancreatitis seen in humans associated with PDAC. A suitable model will display a
transient state from acinar-ductal meta-plasia (ADM) to PanINs without progressing to cancer.
Such a model would provide the chance to examine the precursor to PDAC and potentially pave
the way towards designing new treatment options. | en_US |
dc.description.sponsorship | Jay and Jeanie Schottenstein Honors Program | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Yeshiva College | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Pancreatitis --Research. | en_US |
dc.subject | Pancreas --Cancer --Research. | en_US |
dc.title | Investigating the Roles of SMAD4 and TGF-α in Promoting Metaplasia and Pancreatitis | en_US |
dc.type | Thesis | en_US |