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Cognitive impairment is a significant and life-altering consequence of both multiple sclerosis
(MS) and Alzheimer’s disease (AD). Exercise is more commonly being explored as a mode
of management and possibly improvement of cognitive impairment and memory loss in these
diseases. Studies have shown significant correlation between fitness and degree of cognitive
function in MS, and rate of cognitive decline in AD. Similarities between the aging
population and those with MS and AD supports the notion that physical activity can help
improve brain health and function, and slow down cognitive decline. A randomized
controlled trial has yet to prove a positive effect of implemented exercise training on
cognitive and brain function in MS. While few intervention studies have shown mildly
positive results in AD, further research is needed in both fields to determine particular types
of exercise that are most effective. The current research is in favor of a physically active
lifestyle before the onset of old age to promote overall brain health and lesser cognitive
impairment in both MS and AD.