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Title: Hydrogenase Enzymes and Their Synthetic Models: The Role of Metal Hydrides.
Authors: Schilter, David
Camara, James M.
Huynh, Mioy T
Hammes-Schiffer, Sharon
Rauchfuss, Thomas B.
Keywords: Hydrogenase Enzymes
synthetic models
metal hydrides
Issue Date: 2016
Publisher: American Chemical Society
Citation: Schilter, David, Camara, James M., Huynh, Mioy T., Hammes Schiffer, Sharon and Rauchfuss, Thomas B. (2016). Hydrogenase Enzymes and Their Synthetic Models: The Role of Metal Hydrides. Chemical Review 116: 8693-8749.
Series/Report no.: Chemical Reviews;116
Abstract: Hydrogenase enzymes efficiently process H2 and protons at organometallic FeFe, NiFe, or Fe active sites. Synthetic modeling of the many H2ase states has provided insight into H2ase structure and mechanism, as well as afforded catalysts for the H2 energy vector. Particularly important are hydride-bearing states, with synthetic hydride analogues now known for each hydrogenase class. These hydrides are typically prepared by protonation of low-valent cores. Examples of FeFe and NiFe hydrides derived from H2 have also been prepared. Such chemistry is more developed than mimicry of the redox-inactive monoFe enzyme, although functional models of the latter are now emerging. Advances in physical and theoretical characterization of H2ase enzymes and synthetic models have proven key to the study of hydrides in particular, and will guide modeling efforts toward more robust and active species optimized for practical applications.
ISSN: 0009-2665
Appears in Collections:Faculty Publications

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