Description
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Mentor: Josefa Steinhauer, Ph.D., Department of Biology
Abstract
The piRNA pathway has previously been shown to play a vital role in germline
development in Drosophila through transposon repression. Through individualization complex staining and scoring techniques, fertility tests, and cytological analysis, this thesis focuses on expanding the understanding of the role of the piRNA pathway to include contributions to somatic stem cell development and to show the involvement of the RNAi pathway in spermatogenesis as well. A functional redundancy between the piRNA and RNAi pathways has been uncovered through these experiments as a result of an enhanced phenotype caused by simultaneous mutations in both pathways.
Citation
Re-evaluating the Role of the piRNA Pathway in Germline Development in Drosophila. Borck, Jacob J. Thesis submitted in partial fulfillment of the requirements of the Jay and Jeanie Schottenstein Honors Program, Yeshiva College, Yeshiva University, May 2018.
*This is constructed from limited available data and may be imprecise.