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dc.contributor.advisorCamara, James
dc.contributor.authorSchiff, Elliot
dc.identifier.citationSchiff, Elliot. (July 2019). Methods of Determining Enantiomeric Excess of Secondary Phosphines. Thesis Submitted in Partial Fulfillment of the Requirements of the Jay and Jeanie Schottenstein Honors Program. Yeshiva College, Yeshiva Universityen_US
dc.descriptionSenior thesisen_US
dc.description.abstractAbstract Secondary Phosphines can be directly synthesized through P-C cross-coupling.1 However, there is no published method for determining the enantiomeric excess of secondary phosphines. Development of a method to measure the enantiomeric excess of secondary phosphines is crucial for the ongoing utility of these compounds in pharmaceutical and industrial applications. Using phenyl(xylyl) phosphine as a test case, a series of chiral shift reagents were employed to find a method of determining the enantiomeric excess. Following this, several chiral derivatization agents were employed to convert phenyl(xylyl) phosphine into a pair of identifiable diastereomers to allow measuring the enantiomeric excess. The most promising option was R-menthyl-chloroformate, although the conversion percentage did not exceed 30%.en_US
dc.description.sponsorshipThe Jay and Jeanie Schottenstein Honors Programen_US
dc.publisherNY: Yeshiva College. Yeshiva University.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.subjectSenior honors thesisen_US
dc.subjectSecondary phosphines -- Enantiomeric excessen_US
dc.titleMethods of Determining Enantiomeric Excess of Secondary Phosphines.en_US

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States