• Login as Editor
    View Item 
    •   Yeshiva Academic Institutional Repository
    • Albert Einstein College of Medicine (AECOM)
    • Albert Einstein College of Medicine: Doctoral Dissertations
    • View Item
    •   Yeshiva Academic Institutional Repository
    • Albert Einstein College of Medicine (AECOM)
    • Albert Einstein College of Medicine: Doctoral Dissertations
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    On Evolutionary Dynamics: Theory and Experiments

    Thumbnail

    Date
    2018
    Author
    Pechuan Jorge, Joaquin
    Metadata
    Show full item record
    Share
    Abstract
    After the first life forms emerged, the primitive organization of these protobiotic systems must have imposed severe constraints in the metabolic networks that they were able to encode. A solid hypothetical candidate for a primordial organization of life is the RNA ribocell or more commonly denominated the protocell. The protocell model encapsulates a set of replicating sequences that are both enzymes and genes, modelling a likely scenario given the RNA world theory in which RNA constituted both the catalytic and the informational component of living systems. The need to perform both functions in the context of the populations dynamics of the protocell establishes severe constraints that determine the metabolic networks that can be encapsulated. To address the effect of these constraints, we developed an intermediate complexity model of metabolism that captures enzyme saturation and evaluated how different network organizations evolve in the protocell model. Additionally, we considered the evolution of bacterial populations under fluctuating environments by performing a laboratory evolution experiment with Escherichia coli to determine the genetic adaptations under different types of environmental fluctuations and their effect in the overall phenotypic signature in each environment.
    Permanent Link(s)
    https://hdl.handle.net/20.500.12202/5358
    https://ezproxy.yu.edu/login?url=http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqm&rft_dat=xri:pqdiss:11014740
    Citation
    Source: Dissertations Abstracts International, Volume: 80-06, Section: B.;Publisher info.: Dissertation/Thesis.;Advisors: Bergman, Aviv.
    *This is constructed from limited available data and may be imprecise.
    Collections
    • Albert Einstein College of Medicine: Doctoral Dissertations [1674]

    Yeshiva University Libraries copyright © 2021  DuraSpace
    YAIR Self-Deposit | YAIR User's Guide | Take Down Policy | Contact Us
    Yeshiva University
     

     

    Browse

    AllCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

    My Account

    Login as Editor

    Statistics

    View Usage Statistics

    Yeshiva University Libraries copyright © 2021  DuraSpace
    YAIR Self-Deposit | YAIR User's Guide | Take Down Policy | Contact Us
    Yeshiva University