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dc.contributor.advisorViswanathan, Rajalakshmi
dc.contributor.authorWalder, Mordechai A.
dc.contributor.authorYeshiva University, degree granting institution.
dc.identifier.citationWalder, Mordechai A. Meta-DPI: A Computational Metamethod for Predicting Protein-Protein Interfaces. Thesis Submitted in Partial Fulfillment of the Requirements of the Jay and Jeanie Schottenstein Honors Program. NY: Yeshiva College. Yeshiva University, May 2020. Mentor: Dr. Rajalakshmi Viswanathan, Professor and Co-chair Department of Chemistry.en_US
dc.descriptionSenior honors thesis. Open Access.en_US
dc.description.abstractProtein-protein interactions (PPIs) regulate many biological processes that are integral for the survival, function, growth, and evolution of organisms. Determination of the amino acid residues at these interaction sites, or interfaces, enhances our understanding of the molecular mechanisms by which proteins carry out their functions, and it facilitates the development of therapeutics by identifying critical sites for disrupting protein function. Due to the timeconsuming and costly nature of experimental approaches for identifying interacting residues, computational methods are employed to streamline the process. This work describes the development of meta-DPI, a computational metamethod for predicting protein-protein interfaces that integrates the orthogonal prediction methods DockPred, PredUs 2.0, and ISPRED4. Crossvalidation experiments on two datasets containing a total of 223 protein complexes illustrate that meta-DPI significantly outperforms each of its three constituent methods (DockPred, PredUs 2.0, and ISPRED4) as measured by both single-threshold and threshold-free evaluation metrics. The enhanced predictive power of meta-DPI demonstrates how metamethods create improved interface predictors, which in turn, enable molecular mechanisms to be understood more thoroughly and drug targets to be identified more efficiently.en_US
dc.description.sponsorshipJay and Jeanie Schottenstein Honors Programen_US
dc.publisherNew York, NY: Yeshiva College. Yeshiva University.en_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.subjectSenior honors thesisen_US
dc.subjectprotein-protein interfacesen_US
dc.subjectcomputational metamethodsen_US
dc.subjectPredUs 2.0en_US
dc.titleMeta-DPI: A Computational Metamethod for Predicting Protein-Protein Interfaces.en_US

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