• Transcriptional Dynamics During Lens Fiber Cell Differentiation and Novel Insights Into Their Denucleation Process 

  Limi, Saima (ProQuest Dissertations & Theses Global, 2018)

  The temporal and spatial regulation of gene transcription is a central process governing mammalian development and differentiation. Cellular differentiation is executed through coordinated expression of multiple genes, ...
• The Role of Heparan Sulfate Proteoglycans as Co-Receptors of Wnt-signaling during Neural Development. 

  Saied-Santiago, Kristian (ProQuest Dissertations & Theses Global, 2018)

  Cell migration is a hallmark of many biological processes, including development, immunity, and malignancies. In particular, structures part of the nervous system, including synapses and circuitries, are formed and maintained ...
• How Genetic Variation influences Molecular Genomic Phenotypes 

  Johnston, Andrew D. (ProQuest Dissertations & Theses Global, 2018)

  Variation of DNA sequence in the human genome has relatively predictable effects in protein-coding sequences, but is not well understood in the remaining 98% of the genome. A current focus of research is on the sites that ...
• The Role of Homeobox Transcription Factors Six3 and Six6 in Retinal Development 

  Diacou, Raven Gwendolyn (ProQuest Dissertations & Theses Global, 2018)

  The potential of stem cell-based therapeutics has reignited interest and attention to the development of organs and cell fate specification. In patients, irreversible vision loss occurs due to neurodegenerative eye disease. ...
• Runx1 Promotes Murine Erythroid Progenitor Proliferation and Inhibits Differentiation by Preventing Pu.1 downregulation 

  Willcockson, Michael Alton (ProQuest Dissertations & Theses Global, 2018)

  Pu.1 is an ETS family transcription factor (TF) that plays critical roles in erythroid progenitors by promoting proliferation and blocking terminal differentiation. However, the mechanisms controlling expression and ...
• The Molecular Basis For Receptor-Ligand Recognition In the Immunoglobulin Superfamily 

  Gil, Nelson Homero, Jr. (ProQuest Dissertations & Theses Global, 2018)

  The immunoglobulin superfamily (IgSF) is one of the largest in the human proteome, comprising nearly 500 cell-surface and secreted members critical to processes ranging from the modulation of the immune response to the ...
• Elucidating the Enhancer Code in 9p21 Locus Underlying Age-Related Disease Risks 

  Zhu, Yizhou (ProQuest Dissertations & Theses Global, 2018)

  The chromosomal region 9p21.3 is one of the first identified and most replicated risk loci for coronary artery disease (CAD) by genome-wide association studies (GWAS). This ~150 kb long non-coding region was later found ...
• Myelodysplastic Syndrome Progression to Acute Myeloid Leukemia at the Stem Cell Level 

  Chen, Jiahao (ProQuest Dissertations & Theses Global, 2018)

  Myelodysplastic syndromes (MDS) are malignant hematopoietic stem cell-derived disease with poor clinical outcome and overall survival. Overall ~30% of patients with MDS progress to secondary acute myeloid leukemia (sAML), ...
• Route Specific Effects of Lipoprotein Agonists of TLR2 on CD4 T Cell Priming 

  Johndrow, Christopher Taylor (ProQuest Dissertations & Theses Global, 2018)

  Vaccines are currently the most successful prophylactic intervention against many infectious diseases. Subunit vaccines are a promising strategy for the development of novel effective vaccines, however, protein subunits ...
• Iron Homeostasis-Regulatory Pathways mediate Hematopoietic Stem Cell Fate 

  Kao, Yun-Ruei Christine (ProQuest Dissertations & Theses Global, 2018)

  Iron homeostasis-regulatory pathways mediate hematopoietic stem cell fate Hematopoiesis is a highly regulated, step-wise process in which hematopoietic stem cells (HSCs) residing at the top of the hematopoietic hierarchy ...
• Effect of βV-Tubulin on Cellular Function in Malignancy 

  Mathew, Deepti (ProQuest Dissertations & Theses Global, 2018)

  This thesis work focuses on the Class V beta tubulin isotype (βV-tubulin) exploring the premise that cellular function or dysfunction may be mediated by the isotype composition of its microtubules. It expands on a previously ...
• Exploring the PI3Kβ-Rab5 Interface 

  Heitz, Samantha (ProQuest Dissertations & Theses Global, 2018)

  Class I Phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate cell motility, growth, and survival. Class IA PI3Ks are obligate heterodimers that contain a regulatory subunit (p85α/β, p55α/γ, or p50α) and a ...
• Challenging Current Paradigms: Increasing the Efficacy of Radiation Therapy with Novel Radiation Schemes 

  Savage, Talicia (ProQuest Dissertations & Theses Global, 2018)

  Cancer is the second leading cause of death in the United States. Currently over 50% of all patients are treated with radiation therapy (RT). Although RT is frequently used for local control of solid tumors, recent reports ...
• Monosynaptic Cerebellar Modulation of the Substantia Nigra 

  Wahburn, Samantha Gabrielle (ProQuest Dissertations & Theses Global, 2018)

  The survival of an organism depends on its ability to find and consume energy and reproduce in a constantly changing environment. Doing so necessitates a range of movements, but exactly how the brain plans, selects, and ...
• Generation of a Drosophila Model of Intellectual Disability to Investigate the Transcriptional, Behavioral and Neuronal Defects Caused by Mutations in Histone Demethylase KDMS. 

  Zamurrad, Sumaira (ProQuest Dissertations & Theses Global, 2018)

  Mutations in lysine demethylase 5 (KDM5) family histone demethylases cause intellectual disability (ID) in humans. However, the mechanism underlying the cognitive impairment is unknown. KDM5 proteins are multi-domain ...
• Consequences of Chromosome Instability in Mammalian Cells In Vitro and In Vivo 

  Andriani, Grasiella Angelina (ProQuest Dissertations & Theses Global, 2018)

  Chromosomal instability (CIN) is a cellular state with high propensity for chromosome mis-segregation. Ploidy changes, a direct consequence of CIN, have been correlated with impaired cellular fitness and a transcriptional ...
• Neuropsychiatric Lupus: Pathogenic Mechanisms and Novel Therapeutic Strategies 

  Mike, Elise V. (ProQuest Dissertations & Theses Global, 2018)

  Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that predominantly affects women of color. About 20 to 40% of lupus patients suffer from diffuse neuropsychiatric manifestations of SLE (NPSLE), including ...
• BAF180 Bromodomains Differentially Affect PBAF Targeting to Chromatin Subcompartments and Behave Oncogenically in U2-OS Cells 

  Kenworthy, Charles Andrew (ProQuest Dissertations & Theses Global, 2018)

  Chromatin remodeling is a widespread nuclear function that impacts almost every aspect of nuclear physiology. Thus, the action of SWI/SNF chromatin remodelers can impact a broad range of cellular processes. SWI/SNF remodelers ...
• Generation of an In Situ Tumor Vaccine Using Focused Ultrasound-Induced Immune Priming 

  Skalina, Karin A. (ProQuest Dissertations & Theses Global, 2018)

  The goal of cancer treatment is to destroy all malignant cells within the patient's body, thereby preventing metastases or recurrence. This destruction can be achieved, in broad terms, by direct killing of the cells with ...
• Therapeutic Targeting of the Interleukin 1 Receptor Accessory Protein (IL1 RAP) Reveals Novel Oncogenic Functions in Acute Myeloid Leukemia 

  Mitchell, Kelly (ProQuest Dissertations & Theses Global, 2018)

  Leukemia stem cells (LSC) are the defective counterparts of hematopoietic stem and progenitor cells (HSPC) that can give rise to acute myeloid leukemia (AML). LSC have been implicated as drivers of relapse in AML as they ...

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