Evidence suggests that 17beta-estradiol (E2) contributes to the risk of prostate cancer (PCa), whereas the phytochemicals genistein from soy and 3, 3'-diindolylmethane (DIM), derived from indole-3-carbinol (13C) in cruciferous ...

In mammalian cells the Golgi apparatus consists of a series of flattened cisternae localized to the perinuclear region of the cell. The Golgi undergoes extensive and reversible fragmentation into vesicles and tubules during ...

To better understand the role of caveola/caveolins in electrically responsive cells we examined cardiac muscle and urogenital smooth muscle tissues in mice genetically engineered to be caveolin deficient.;Only Cav-3 is ...

Most eukaryotic secretory proteins are synthesized as precursors containing a transient amino-terminal signal peptide of 20-25 amino acids. The signal peptide mediates binding of polysomes to the endoplasmic reticulum (ER) ...

The genetic control of longevity and pro-longevity phenotypes is likely to be determined by subtle variations in many genes involved in multiple genetic pathways. The challenge is to identify the combinations of alleles ...

The nod, no distributive disjunction and ncd, non-claret disjunctional are female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of chromosome nondisjunction ...

Histones are small, basic proteins found in abundance in most eukaryotic cells. The H1 histones bind the linker DNA between nucleosome core particles and facilitate the packaging of chromatin into the 30-nm fiber and higher ...

Classical A kinase anchor proteins (AKAPs) preferentially tether type II protein kinase A (PKAII) isoforms to sites in cytoskeleton and organelles. It is not known if distinct proteins selectively sequester regulatory (R) ...

The regulation of energy utilization in response to changing intracellular and extracellular conditions is key for survival. The Target of Rapamycin Complex 1 (TORC1) plays a central role in signaling nutrient availability, ...