Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 3-22 of 1674
-
A biosensor of S100A4 metastasis factor activation: Inhibitor screening and cellular activation dynamics
(ProQuest Dissertations & Theses, 2008)S100A4, a member of the S100 family of proteins, binds nonmuscle myosin-IIA in a calcium-dependent manner and regulates the monomer-polymer equilibrium of myosin-IIA filaments. S100A4 displays elevated expression in malignant ... -
A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis
(ProQuest Dissertations & Theses, 2002)In mammalian cells the Golgi apparatus consists of a series of flattened cisternae localized to the perinuclear region of the cell. The Golgi undergoes extensive and reversible fragmentation into vesicles and tubules during ... -
A CEREBELLAR ROLE IN CONTROL OF THE GOLDFISH VESTIBULO-OCULAR REFLEX
(ProQuest Dissertations & Theses, 1983)The vestibulo-ocular reflex (VOR) stabilizes gaze by producing eye movements that compensate for head rotations. VOR gain is defined as eye velocity divided by head velocity. Three types of experiments were performed in ... -
A characterization of caveolins/caveolae in cardiac and smooth muscle tissues
(ProQuest Dissertations & Theses, 2004)To better understand the role of caveola/caveolins in electrically responsive cells we examined cardiac muscle and urogenital smooth muscle tissues in mice genetically engineered to be caveolin deficient.;Only Cav-3 is ... -
A Closer Look at Cell Invasion with Biosensors
(ProQuest Dissertations & Theses, 2013)The Rho family of small GTPases control cell motility and migration, and are understood to participate in the regulation of cancer metastasis. Specifically, Rac1 GTPase is overexpressed in several tumors. Invadopodia are ... -
A DIRECT DETERMINATION OF THE MINIMUM SIZE FOR A EUKARYOTIC SECRETORY PRECURSOR (PREPROINSULIN, TRANSLOCATION, SIGNAL SEQUENCE, ENDOPLASMIC RETICULUM, GENE FUSION)
(ProQuest Dissertations & Theses, 1986)Most eukaryotic secretory proteins are synthesized as precursors containing a transient amino-terminal signal peptide of 20-25 amino acids. The signal peptide mediates binding of polysomes to the endoplasmic reticulum (ER) ... -
A dopamine-dependent signal in the nucleus accumbens invigorates reward- seeking behavior
(ProQuest Dissertations & Theses, 2014)Decades of research have implicated ventral striatal dopamine in conditioned appetitive behaviors. We began with the observation that if the ventral striatal dopamine signal is impaired so is the ability of experimental ... -
A functional genomics approach to elucidate the role of genome maintenance in human longevity
(ProQuest Dissertations & Theses, 2014)The genetic control of longevity and pro-longevity phenotypes is likely to be determined by subtle variations in many genes involved in multiple genetic pathways. The challenge is to identify the combinations of alleles ... -
A genetic analysis of NPC1 receptor activity in Ebola virus infection
(ProQuest Dissertations & Theses, 2017)Filoviruses are enveloped, negative-sense, single-stranded RNA viruses that are the causative agents of numerous sporadic outbreaks of viral hemorrhagic fever diseases with case fatality rates up to 90%. Recently, the ... -
A genetic and molecular analysis of two Drosophila meiotic mutants encoding kinesin-like proteins
(ProQuest Dissertations & Theses, 1992)The nod, no distributive disjunction and ncd, non-claret disjunctional are female-specific, recessive meiotic mutations in Drosophila melanogaster. Mutations at either locus show high frequencies of chromosome nondisjunction ... -
A genetic approach to H1 histone function
(ProQuest Dissertations & Theses, 1996)The mouse H1 histone gene family encodes a group of at least seven basic protein variants that bind to DNA and facilitate the formation of higher order chromatin structures. Interestingly, among the histones the H1 class ... -
A genetic approach to the functions of specific H1 linker histones in mammalian spermatogenesis
(ProQuest Dissertations & Theses, 1999)Histones are small, basic proteins found in abundance in most eukaryotic cells. The H1 histones bind the linker DNA between nucleosome core particles and facilitate the packaging of chromatin into the 30-nm fiber and higher ... -
A genetic study of the anti-DNA associated idiotype 8.12: Analysis of 8.12(+) antibodies and autoantibodies, and characterization of the VlambdaII gene family
(ProQuest Dissertations & Theses, 1993)Individuals with systemic lupus erythematosus (SLE) characteristically display high serum titers of autoantibodies directed against a variety of nuclear antigens. While SLE autoantigens typically include both proteins and ... -
A KAPtivating protein: Insights into the function of AKAP-KL
(ProQuest Dissertations & Theses, 2002)Classical A kinase anchor proteins (AKAPs) preferentially tether type II protein kinase A (PKAII) isoforms to sites in cytoskeleton and organelles. It is not known if distinct proteins selectively sequester regulatory (R) ... -
A LIGHT-MICROSCOPIC AND ELECTRON-MICROSCOPIC STUDY ON NUCLEOLAR CONFIGURATIONS IN CELLS OF THE KANGAROO RAT: DIPODOMYS MERRIAMI
(ProQuest Dissertations & Theses, 1973) -
A link between TORC1 and CK2 in S. cerevisiae via the Cdc-like kinase Knsl
(ProQuest Dissertations & Theses, 2016)The regulation of energy utilization in response to changing intracellular and extracellular conditions is key for survival. The Target of Rapamycin Complex 1 (TORC1) plays a central role in signaling nutrient availability, ... -
A MAMMALIAN SITE-SPECIFIC ENDONUCLEASE
(ProQuest Dissertations & Theses, 1981)Recent evidence suggests that site-specific recombination may be important both for genetic rearrangement on an evolutionary scale and for gene control during differentiation. A consideration of the mechanism of recombination ... -
A MORPHOLOGICAL STUDY OF THE BLOOD-AQUEOUS HUMOR BARRIER IN YOUNG AND ADULT ALBINO RABBITS
(ProQuest Dissertations & Theses, 1974) -
A MORPHOPHYSIOLOGICAL STUDY OF THE SUPERIOR VESTIBULAR NUCLEUS IN THE CAT
(ProQuest Dissertations & Theses, 1981)The present study is an attempt to increase the understanding of the role of the superior vestibular nucleus (SVN) in the vestibulooclar reflex (VOR) and, in general, in the control of gaze by brain stem neurons. The prime ... -
A multipronged mechanistic study of the sodium iodide symporter (NIS): Subcellular localization, stoichiometry, transport of the environmental pollutant perchlorate, and purification for structural analysis
(ProQuest Dissertations & Theses, 2011)Iodide (I-) transport in the thyroid, the rate-limiting step in thyroid hormone biosynthesis, is mediated by the Na+/I - symporter (NIS). NIS also mediates I- transport in other polarized epithelia, where NIS is localized ...