BCL6 is a sequence specific transcription repressor required for germinal center (GC) formation. In normal B cells, BCL6 exerts its regulatory role through repression of genes associated with B cell activation, response ...

The B7 family of proteins provides regulatory signals that can either costimulate or coinhibit T cells during both activation and effector phases. B7x is a coinhibitory member of this family whose currently unknown receptor ...

Chromatin remodeling is a widespread nuclear function that impacts almost every aspect of nuclear physiology. Thus, the action of SWI/SNF chromatin remodelers can impact a broad range of cellular processes. SWI/SNF remodelers ...

In goldfish, one of the paired Mauthner (M-) cells, initiates the auditory evoked escape behavior. The behavior is appropriately directional; in the open field a fish reliably turns away from the sound source whereas near ...

S100A4, a member of the Ca2+-activated S100 protein family, regulates the motility and invasiveness of cancer cells. Moreover, high expression levels of S100A4 correlate with poor patient survival in several cancers. ...

Since regulation of DNA replication in Drosophila melanogaster resides in the initiation phase of DNA replication, it was reasoned that accessory factors must exist that would act in collaboration with DNA polymerase alpha ...

The alphavirus Semliki Forest virus (SFV) contains a single-stranded RNA genome bound to the capsid protein and enveloped by a membrane derived from the host cell. The membrane contains two viral glycoproteins, E1 and E2. ...

Persistent infection with a subset of human papillomaviruses (HPVs) has been conclusively shown to be the cause of cervical cancer. Only a small subset of the ∼150 characterized HPVs has been shown to be oncogenic. ...

Most chemotherapeutics currently used in the treatment of Mycobacterium tuberculosis (Mtb) target conventional systems of anti-microbial therapy, like cell wall and DNA biosynthesis. While targeting pathways essential for ...