We have explored the role of calmodulin (CaM) in the regulation of a number of immunologically important cellular functions expressed by macrophages, such as phagocytosis, enzyme secretion, and migration. We chose the ...

Carboxypeptidase A6 (CPA6) is a protease that removes C-terminal hydrophobic residues from peptides and proteins. The CPA6 gene is expressed in the central nervous system of vertebrates, including humans. It is translated ...

With a focus on cardiac remodeling and metabolic disorders, we applied cardiac MRI, among other monitoring techniques, in a serial non-invasive study in mouse models. Our interest in the therapeutic potential of endothelial ...

Anthrax is a bacterial disease caused by Bacillus anthracis, which has gained notoriety for its potential use as a biological weapon. Anthrax-induced morbidity and mortality in mammalian hosts is associated with the release ...

Caveolin-1 is the principal coat protein of caveolae membranes. This protein is also a component of the cell's transport machinery, contributing to the bi-directional traffic of cholesterol to and from caveolae. Third, ...

Malaria is a significant global health burden, causing death in half a million people every year. High levels of inflammatory cytokines are thought to be one important contributor to severe disease, yet few studies have ...

Maternal nutritional status can have short-term and long-term effects on offspring growth, development and health. Those born with extremely low birth weight are more likely to develop cardiovascular disease, type 2 diabetes ...