Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 339-358 of 1674
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Deciphering neuronal dysfunction in Tau pathology
(ProQuest Dissertations & Theses, 2010)A hallmark feature of Alzheimer's disease pathology is the presence of neurofibrillary tangles (NFTs), which are intracellular aggregates of conformationally abnormal and hyperphosphorylated tau. Tau function is important ... -
Deciphering the Regulation of Cytoplasmic Dynein's Attachment to Microtubules
(ProQuest Dissertations & Theses, 2013)Cytoplasmic dynein is a homodimeric microtubule (MT) motor responsible for most MT minus-end-directed transport in eukaryotes. Its function is critically important to both health and disease.;Unlike other cytoskeletal motor ... -
Deciphering the role of SF3B1 in hematopoiesis
(ProQuest Dissertations & Theses, 2017)Hematologic malignancies claim the lives of many people every year, yet we lack a complete understanding of the mechanisms of pathogenesis behind them. Myelodysplastic Syndromes (MDS) are a group of hematologic malignancies ... -
Deciphering the Transcriptional Networks Regulated by Two Hematopoietic Master Regulatory Transcription Factors, PU.1 and GATA-1
(ProQuest Dissertations & Theses, 2011)Lineage-specification involves the activation of lineage-specific genes and the inhibition of alternative lineages by master regulatory transcription factors (MRTFs). Previous work from our lab showed PU.1, a MRTF of ... -
Deconstructing nicotine cue reactivity: cortical control, PKG-dependent maintenance, and incentive-withdrawal interaction
(ProQuest Dissertations & Theses, 2011)Tobacco smoking represents a major health crisis worldwide. Nicotine is a major component of tobacco that induces dependence. In dependent smokers, cues associated with smoking contribute to persisted smoking, craving, and ... -
Decoy strategies: The structural and biochemical characterization of TL1A, DcR3 and their interactions
(ProQuest Dissertations & Theses, 2010)The Tumor Necrosis Factor (TNF) and TNF receptor (TNFR) superfamilies represent major classes of co-stimulatory molecules and play critical roles in immunity. Decoy Receptor 3 (DcR3) is a secreted TNFR that is highly ... -
DEGENERATION AND REGENERATION OF THE VIIITH CRANIAL NERVE IN SALAMANDER (AMBYSTOMA MEXICANUM) LARVAE (MAUTHNER CELL, REINNERVATION, HORSERADISH PEROXIDASE, VERTIBULAR NERVE, AXONAL REGENERATION)
(ProQuest Dissertations & Theses, 1986)To investigate nerve regeneration in the central nervous system of a lower vertebrate, the vestibular or VIIIth cranial nerve (nVIII) root was transected unilaterally in salamander, Ambystoma mexicanum, larvae. Regenerating ... -
DENERVATION SUPERSENSITIVITY: THE EFFECTS OF CHRONIC NEURAL ISOLATION ON SOME PHYSIOLOGICAL AND PHARMACOLOGICAL CHARACTERISTICS OF CEREBRAL CORTEX
(ProQuest Dissertations & Theses, 1961) -
DEOXYRIBOKINASE FROM SALMONELLA TYPHIMURIUM: PURIFICATION AND PROPERTIES
(ProQuest Dissertations & Theses, 1969) -
Deriving Novel Insights from Genomic Heterogeneity in Cancer
(ProQuest Dissertations & Theses Global, 2018)Cancer is a leading cause of morbidity and mortality, and one in three individuals in the U.S. will be diagnosed with cancer in their lifetime. At the molecular level, cancer is driven by the activity of oncogenes and the ... -
Design and synthesis of small molecule inhibitors of protein tyrosine phosphatase 1B
(ProQuest Dissertations & Theses, 2001)Protein tyrosine phosphatase 1B (PTP1B) has been clearly implicated as a negative regulator of insulin signaling and its overexpression or high activity has been closely associated with human diseases such as diabetes and ... -
Determinants of Subcellular Trafficking of Organic Anion Transport Protein 1a1 (oatp1a1)
(ProQuest Dissertations & Theses, 2011)Uptake of organic anionic compounds from the blood is a major function of the liver. These include endogenous compounds such as bilirubin and bile acids as well as xenobiotics such as drugs and toxins. Transporters that ... -
Developing chemoenzymatic tools for studying cell-surface glycans
(ProQuest Dissertations & Theses, 2014)Glycosylation is a posttranslational modification, not under direct genetic control. The combinatorial action of many glycosyltransferases in competing biosynthetic pathways renders cellular glycans difficult to predict ... -
Developing herpes simplex virus type 1 amplicon vectors for gene therapy: Hepatic gene transfer and steroid-inducible gene expression
(ProQuest Dissertations & Theses, 1996)Herpes simplex virus type 1 (HSV-1) amplicon vector is packaged from a conventional prokaryotic plasmid that contains HSV cis-elements for DNA replication and packaging. We tested the hypotheses that HSV-1 amplicon vector ... -
Development and analysis of immune-based therapy to treat HIV infection
(ProQuest Dissertations & Theses, 2014)Immune-based therapeutics that harness the immune system have significant potential inhibit HIV-1 infection. We investigated whether an interleukin-15 (IL-15) superagonist (ALT-803) activated and mobilized natural killer ... -
Development and application of a rapid site -specific integration system in the malaria parasite Plasmodium falciparum
(ProQuest Dissertations & Theses, 2006)The current transfection techniques for genomic integration and complementation studies in the malaria parasite, Plasmodium falciparum, are inefficient and labor-intensive. It takes 3-5 months to achieve genetic integration ... -
Development and utilization of novel HIV-1 infectable mouse models to evaluate HIV-1 treatment, prevention, and pathogenesis
(ProQuest Dissertations & Theses, 2015)Development and utilization of novel HIV-1 infectable mouse models to evaluate HIV-1 treatment, prevention, and pathogenesis Almost 78 million people have been infected with human immunodeficiency virus (HIV) since the ... -
Development of a common pharmacophore model for taxol and the epothilones
(ProQuest Dissertations & Theses, 2000)Taxol is an anticancer drug approved by the FDA for the treatment of ovarian, breast and lung carcinomas. The drug hyperstabilizes microtubules, disrupts normal microtubule organization and dynamics, blocks cells in mitosis, ... -
Development of a synchronized assembly assay and investigation of herpes simplex virus-1 maturation
(ProQuest Dissertations & Theses, 1999)To investigate late events in Herpes Simplex Virus (HSV) assembly, we have developed an assay system which allows HSV assembly to be synchronized in infected cells. This synchronous assay makes use of the reversible ... -
Development of efficient tools for analysis of the host -parasite interaction during the liver stages of malaria infection
(ProQuest Dissertations & Theses, 2009)The morbidity and mortality due to malaria is rising as a result of the emergence and spread of drug resistant parasites and the lack of an effective vaccine. Development of novel intervention strategies is hindered by the ...