Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 540-559 of 1674
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Gamma rhythm and its relationship with neuronal activity in early visual cortex
(ProQuest Dissertations & Theses, 2012)The gamma components (30-50 Hz) of the local field potentials (LFPs) are correlated with numerous perceptual and cognitive phenomena, and have been proposed to have important functions in sensory processing. Despite its ... -
Ganglioside expression and function in development and disease
(ProQuest Dissertations & Theses, 2001)This thesis dissertation examines the role of gangliosides in neocortical development and in genetic brain disease. The morphological changes that ferret neocortical pyramidal neurons undergo during basilar dendritic growth ... -
GENE ORGANIZATION AND GENETIC EXPRESSION OF HEPATITIS B VIRUS: RNA AND DNA STUDIES IN A HUMAN HEPATOMA CELL LINE AND IN LONG-TERM CHIMPANZEE HBV CARRIERS
(ProQuest Dissertations & Theses, 1982)The studies presented in this thesis are concerned with gene organization and function of Hepatitis B virus DNA sequences in a human hepatoma cell line (PLC/PRF/5) which expresses hepatitis B surface antigen and in the ... -
Gene Regulation by Pax6 in Mammalian Lens Development
(ProQuest Dissertations & Theses, 2011)Gene regulatory networks (GRNs) play critical roles during embryonic development and evolution. Lens development represents an advantageous system to identify specific GRNs as each stage of lens formation is characterized ... -
Generating new mouse models for the study and treatment of type 1 diabetes
(ProQuest Dissertations & Theses, 2014)Type 1 diabetes (T1D) is an autoimmune disease resulting from the T cell-mediated destruction of pancreatic beta cells. Many genetic susceptibility factors associated with T1D development have also been found in the non-obese ... -
GENERATION AND CHARACTERIZATION OF I-E(D) MUTANTS FROM AN ANTIGEN PRESENTING MACROPHAGE CELL LINE (SOMAHI GENETICS, IA MOLECULES)
(ProQuest Dissertations & Theses, 1986)Ia molecules on antigen presenting cells function as restriction elements in the recognition of antigen by T lymphocytes. In order to learn more about structure-function relationships of Ia antigens, structural I-E('d) ... -
Generation of a Drosophila Model of Intellectual Disability to Investigate the Transcriptional, Behavioral and Neuronal Defects Caused by Mutations in Histone Demethylase KDMS.
(ProQuest Dissertations & Theses Global, 2018)Mutations in lysine demethylase 5 (KDM5) family histone demethylases cause intellectual disability (ID) in humans. However, the mechanism underlying the cognitive impairment is unknown. KDM5 proteins are multi-domain ... -
Generation of an In Situ Tumor Vaccine Using Focused Ultrasound-Induced Immune Priming
(ProQuest Dissertations & Theses Global, 2018)The goal of cancer treatment is to destroy all malignant cells within the patient's body, thereby preventing metastases or recurrence. This destruction can be achieved, in broad terms, by direct killing of the cells with ... -
Generation of NIS mutants with altered substrate specificity and Na+/Anion stoichiometry: potential therapeutic implications for NIS gene transfer
(ProQuest Dissertations & Theses, 2010)Active I- transport into the thyroid gland for thyroid hormone biosynthesis is mediated by the Na+/I - symporter (NIS). I- uptake by NIS is electrogenic: 2 Na+ are translocated with each I- . I- transport defect (ITD) is ... -
Genetic analysis of a mutation defective in chromosome partner choice
(ProQuest Dissertations & Theses, 1989)This report describes the isolation and characterization of Aberrant X segregation (Axs), a dominant female-specific meiotic mutation in Drosophila melanogaster. Axs has little or no effect on the frequency or distribution ... -
Genetic analysis of an antigen-induced model of systemic lupus erythematosus
(ProQuest Dissertations & Theses, 2005)Systemic lupus erythematosus (SLE) is an autoimmune disease with the capacity to impact multiple organ systems. SLE is a complex disorder involving a combination of environmental, gender and genetic factors to initiate ... -
Genetic analysis of novel loci in the kal-1 pathway
(ProQuest Dissertations & Theses, 2014)The development of the nervous system is a complex process through which many cues and instructions need to be followed to form a functional unit. KAL1 regulates neuronal branching and cell migration through mechanisms ... -
Genetic analysis of pellicle formation in Mycobacterium tuberculosis: New insights into an old foe
(ProQuest Dissertations & Theses, 2012)The genus name Mycobacterium means fungus-like bacterium, reflecting the observation that the tubercle bacilli are capable of growing on the surface of media as mold-like pellicles. Despite this early observation, ... -
Genetic analysis of revertant alleles of Axs(D), a meiotic mutation in Drosophila melanogaster
(ProQuest Dissertations & Theses, 1994)The regular segregation of achiasmate chromosomes during the first meiotic division in Drosophila melanogaster females is ensured by two distinct segregational systems. The segregation of achiasmate homologs is assured by ... -
Genetic and biochemical control of phospholipid biosynthesis in Saccharomyces cerevisiae
(ProQuest Dissertations & Theses, 1988)Phospholipid biosynthesis is a highly regulated process in the budding yeast Saccharomyces cerevisiae. This regulation has both genetic and biochemical components. Genetic control is involved in the long-term tailoring of ... -
GENETIC AND MOLECULAR REGULATION OF INOSITOL BIOSYNTHESIS AND ITS COORDINATION WITH PHOSPHOLIPID BIOSYNTHESIS IN SACCHAROMYCES CEREVISIAE
(ProQuest Dissertations & Theses, 1983)The regulation of membrane biogenesis in a program of balanced cell growth is comprised of numerous complex interactions. Two components of this process are: (1) the regulation of the synthesis of phospholipid precursors, ... -
Genetic and molecular studies of Caenorhabditis elegans male tail development
(ProQuest Dissertations & Theses, 1993)The Caenorhabditis elegans male tail sensory organs provide a simple model system in which to study the role of genetic specification and organization of the peripheral nervous system. Mutations resulting in male tail ... -
Genetic and molecular studies of thenod locus: A putative microtubule motor required in Drosophila female meiosis
(ProQuest Dissertations & Theses, 1990)The female-specific {dollar}nod\sp{lcub}a{rcub}{dollar} mutation induces meiotic nondisjunction of nonexchange chromosomes in the distributive system, and the mitotic loss of maternally derived chromosomes in early cleavage ... -
Genetic dissection of baseline and stress-induced serotonin biosynthesis in Caenorhabditis elegans ADF chemosensory neurons
(ProQuest Dissertations & Theses, 2015)This thesis presents a genetic analysis of three independent regulatory programs that govern serotonin biosynthesis enzyme tph-1 gene expression in a pair of serotonergic chemosensory neuron ADF in the nematode Caenorhabditis ... -
GENETIC MECHANISMS AFFECTING IMMUNOGLOBULIN GENE EXPRESSION
(ProQuest Dissertations & Theses, 1982)Immunoglobulin genes are regulated by a complex set of mechanisms which cause major DNA rearrangements and create antigen binding diversity. Characterization of Ig variants which express structurally altered heavy chains ...