Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 571-590 of 1674
-
Hacking the Immune System to Cure HIV-1: Potent Elimination of HIV-1-Infected Cells by Antibody Based Therapeutics
(ProQuest Dissertations & Theses Global, 2018)The development of a functional cure against HIV-1 infection is prevented by the ability of the virus to evade immune responses by mutating rapidly and establishing latency. Treatment of HIV-1-infected patients with latency ... -
Hallmarks of Molecular Action of Microtubule Stabilizing Agents: A Comprehensive H-D Exchange Profile of Drug-Stabilized Chicken Erythrocyte Microtubules
(ProQuest Dissertations & Theses, 2010)Microtubule stabilizing agents (MSAs) comprise a class of drugs that bind to microtubule (MT) polymers and stabilize them against disassembly. Several of these agents are currently in clinical use as anticancer drugs, while ... -
Helios regulates interleukin-2 expression and suppressive function in natural regulatory T cells
(ProQuest Dissertations & Theses, 2012)The critical role of regulatory T cells in maintaining immune tolerance and preventing autoimmune disease has been well established. Treg cells express the transcription factor Foxp3, which acts as a master regulator of ... -
Hemopoietic growth factor purification and action
(ProQuest Dissertations & Theses, 1987)Hemopoiesis involves a continuous process of cell proliferation and differentiation which leads to the production of functional circulatory blood cells. The proliferation and maturation of hemopoietic cells is dependent ... -
Hepatitis B virus open reading frame X
(ProQuest Dissertations & Theses, 1992)Sequence analysis of the hepatitis B virus (HBV) genome revealed the presence of an open reading frame (ORF X) which has the potential to encode a 154 amino acid polypeptide. I constructed two recombinant plasmids, each ... -
Herpes simplex virus assembly and intracellular trafficking during viral egress
(ProQuest Dissertations & Theses, 2005)Herpes simplex virus (HSV) has evolved to efficiently reorganize the host cell secretory pathway and cytoskeletal elements to achieve virus assembly and exocytosis. The assembly of viral components and the intracellular ... -
Heterosynaptic potentiation of inhibitory synapses in the hippocampus
(ProQuest Dissertations & Theses, 2010)Both excitatory and inhibitory synapses are subject to activity-dependent changes that are crucial for experience-driven refinement of neuronal circuits such as take place during development and memory formation. Pre-, ... -
HGF mediates breast tumor cell migration towards blood vessels
(ProQuest Dissertations & Theses, 2017)In the United States, around 40,000 women are expected to die every year from breast cancer and one of eight women will develop breast cancer through their lifetime. The major reason for these deaths from cancer is due to ... -
HHLA2 and TMIGD2 are two novel members of the B7-CD28 immune checkpoint family
(ProQuest Dissertations & Theses, 2017)HHLA2 is a newly identified B7 family member that inhibits T cell function. Little is known about its expression and what biological functions it serves. Here we extensively assess protein expression of HHLA2 in a wide ... -
HIERARCHICAL REGULATION OF FLAGELLAR BIOGENESIS IN CAULOBACTER CRESCENTUS
(ProQuest Dissertations & Theses, 1987)The assembly of a functional flagellum in the bacterium Caulobacter crescentus requires the protein products of approximately 30 genes expressed in temporally-discrete and spatially-distinct manner. Our current understanding ... -
High affinity binding proteins for the regulatory subunit of cAMP-dependent protein kinase: Cloning, characterization and expression of P150 and P75
(ProQuest Dissertations & Theses, 1989)cAMP-dependent protein kinase II-B appears to be adapted for function in the mammalian central nervous system (CNS) via the properties of its regulatory subunit (RII-B). RII-B is selectively expressed in brain, tightly ... -
High resolution dynamic maps of the timing of DNA replication using TimEX
(ProQuest Dissertations & Theses, 2009)The development of lentiviral vectors greatly improved the prospects of gene therapy. Several groups have used such vectors to cure hemoglobinopathies in mouse models1. Nevertheless, viral integrations are random causing ... -
HISTAMINE AND SEROTONIN RECEPTORS ON CULTURED SMOOTH MUSCLE CELLS
(ProQuest Dissertations & Theses, 1982)The purpose of this thesis was to pharmacologically characterize histamine and serotonin receptors linked to adenylate cyclase on cultured calf aorta smooth muscle cells. First, the effects of specific agonists and antagonists ... -
Histone variant macroH2A1 plays an isoform-specific role in suppressing Epithelial-Mesenchymal Transition
(ProQuest Dissertations & Theses, 2017)Epithelial-Mesenchymal Transition (EMT) is a biological program in which epithelial cells lose their characteristics of apical-basal polarity, reduce expression of intercellular adhesion proteins with neighboring cells and ... -
HIV-I modulates the survival and proliferation of microglia in HIV encephalitis and in a culture model
(ProQuest Dissertations & Theses, 2004)Despite the advent of HAART, HIV-associated dementia remains a significant disease in AIDS patients. Productive infection of parenchymal microglia in HIV encephalitis (HIVE) has been recognized, but its relative importance ... -
HIV-Infection Dysregulates MicroRNA Expression by Human Macrophages
(ProQuest Dissertations & Theses, 2011)Over 33 million people are infected with the Human Immunodeficiency Virus (HIV) worldwide. As the first cells infected during the pathogenesis of HIV, macrophages release virus and inflammatory factors over long periods ... -
HORMONAL INDUCTION OF MEIOTIC MATURATION IN OVARIAN FOLLICLES OF RANA PIPIENS
(ProQuest Dissertations & Theses, 1978) -
HORMONAL REGULATION OF ATP CITRATE LYASE PHOSPHORYLATION IN 3T3-L1 ADIPOCYTES
(ProQuest Dissertations & Theses, 1983)ATP citrate lyase was purified to homogeneity form murine liver. In vitro the purified enzyme served as a good substrate for the catalytic subunit of cAMP-dependent protein kinase, accepting up to one mol of covalently ... -
Host and parasite factors associated with brain swelling in pediatric cerebral malaria
(ProQuest Dissertations & Theses, 2015)Malaria is a mosquito-borne illness caused by Plasmodium spp . parasites. In 2013, there was an estimate of 198 million malaria cases with 584,000 deaths worldwide. In infections with P. falciparum , cerebral malaria (CM), ... -
Host immune responses to Listeria monocytogenes infection in the pregnant mouse
(ProQuest Dissertations & Theses, 2009)The success of viviparity, or live births of the young, in mammalian species depends on strict regulation of the maternal immune system during pregnancy to induce and maintain tolerance of the fetus that also expresses ...