Colony Stimulating Factor-1 (CSF-1) transduces mitogenic and differentiation signals in mononuclear phagocytes by binding and activating its cognate receptor tyrosine kinase, causing the rapid tyrosine phosphorylation of ...

The end goal of mitosis is equal partitioning of genetic material into respective daughter cells. When this is not achieved, genomic instability may result, the end result of which may be cancer. The mitotic spindle, a ...

Encapsulation of proteins in porous sol-gels is a promising technique both for the development of new classes of biosensors and for biophysical studies of unstable protein conformations. This thesis focuses on the development ...

Detergent-solubilized extracts of 3T3-L1 cells contained 40% more insulin binding activity than could be detected on the cell surface. The size of this cryptic pool was not altered when 95% of cell surface receptors were ...

A series of anesthetized and conscious dog experiments and computational model experiments was performed to investigate the role of the left atrium in filling the left ventricle. Computer hardware and software were designed ...

Lens fiber cell differentiation is characterized by cell elongation, accumulation of crystallins and other lens-specific proteins and coordinated degradation of subcellular organelles, including the nucleus. Destruction ...

The success of any bacterial pathogen depends greatly on the balance between pathogenicity and host antimicrobial responses. To successfully persist in a host, a bacterial pathogen must not only evade the immune response, ...

The world is currently suffering from an epidemic of obesity, likely due to the "western diet" high in fat, sugar and cholesterol, that has become a major public health issue, especially in developed countries. Obesity is ...