Detergent-solubilized extracts of 3T3-L1 cells contained 40% more insulin binding activity than could be detected on the cell surface. The size of this cryptic pool was not altered when 95% of cell surface receptors were ...

A series of anesthetized and conscious dog experiments and computational model experiments was performed to investigate the role of the left atrium in filling the left ventricle. Computer hardware and software were designed ...

Lens fiber cell differentiation is characterized by cell elongation, accumulation of crystallins and other lens-specific proteins and coordinated degradation of subcellular organelles, including the nucleus. Destruction ...

The success of any bacterial pathogen depends greatly on the balance between pathogenicity and host antimicrobial responses. To successfully persist in a host, a bacterial pathogen must not only evade the immune response, ...

The world is currently suffering from an epidemic of obesity, likely due to the "western diet" high in fat, sugar and cholesterol, that has become a major public health issue, especially in developed countries. Obesity is ...

At confluence, fibroblast-like 3T3-L1 cells undergo terminal differentiation acquiring the morphological and physiological characteristics of tissue adipocytes. Enzyme cytochemistry (Novikoff, et al., J. Cell Biol. 87:180, ...

In cancer, EGF plays a substantial role in inducing tumor cell movement. However, the mechanisms by which cells respond to concentration gradients of this chemoattractant are poorly understood. To model this process, we ...

The degeneration of basal forebrain cholinergic neurons with corresponding reductions in cholinergic innervation to the neocortex is a characteristic neuropathological feature of Alzheimer's disease. The mechanism responsible ...