Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 760-779 of 1674
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M. smegmatis IKEPLUS Immunization Reveals the Mycobacterial Ribosome as a Source of Novel CD4+ T cell Antigens
(ProQuest Dissertations & Theses, 2018)No vaccine candidate has had major success in reducing the enormous global burden of disease due to Mycobacterium tuberculosis (Mtb). Critical to the control of Mtb is the ability of a vaccine to induce a strong CD4+ Tcell ... -
Macroautophagy and protein aggregate formation in lysosomal disease
(ProQuest Dissertations & Theses, 2013)Lysosomal diseases comprise a group of nearly 60 distinct disorders characterized by dysfunction of the lysosomal system. While most of these disorders present with systemic involvement, nearly two-thirds are associated ... -
Macroautophagy regulates CD4+ T cell function
(ProQuest Dissertations & Theses, 2011)Protein turnover is imperative for the diminution and removal of accumulated damaged proteins in the cell. Turnover is also essential to facilitate recycling of amino acids for new protein synthesis and to allow for the ... -
Major Facilitator Superfamily Domain-containing protein 2a is a novel PPAR-alpha target with roles in body growth, motor function, and lipid metabolism
(ProQuest Dissertations & Theses, 2012)Understanding how the body switches between storing and burning energy is fundamental to our ability to better treat metabolic disease. The metabolic adaptations to fasting in the liver are largely controlled by the nuclear ... -
Malaria parasite purine transporters: Function determination & inhibitor identification
(ProQuest Dissertations & Theses, 2013)Malaria is a disease that continues to affect hundreds of millions of people in tropical regions of the world every year. The parasite species Plasmodium falciparum and Plasmodium vivax cause the most virulent and prevalent ... -
Mapping functional domains in myosin
(ProQuest Dissertations & Theses, 1990)Two general approaches were taken to learn more about how structure relates to function in myosin. One approach involved the development of an expression system in which mutants of myosin could be generated and assayed. ... -
Mapping the functional surfaces of two signal transduction proteins
(ProQuest Dissertations & Theses, 2001)The modern methodology to characterize protein-ligand interactions at the atomic level encompasses structural, mutagenesis, and functional studies. This multidisciplinary approach has been employed to characterize the ... -
Mapping the membrane topology of the diphtheria toxin channel: A study in molecular cartography
(ProQuest Dissertations & Theses, 1994)Diphtheria Toxin (DT) is a 65 kD, two chain, protein. Its N-terminal A fragment kills cells by enzymatically inactivating their protein synthetic machinery, while its C-terminal B-fragment (40 kD) is required for binding ... -
Mapping the Solvent Accessible Surface Area of Proteins using Pyrite Nanocrystals: Bringing Oxidative Footprinting onto the Bench
(ProQuest Dissertations & Theses, 2016)Mapping the Solvent Accessible Surface Area of Proteins using Pyrite Nanocrystals: Bringing Oxidative Footprinting onto the Bench Mapping a protein's solvent accessible surface provides insight into structure and assembly ... -
Maternal systemic lupus erythematosus (SLE): Congenital cortical impairment and offspring sex ratio imbalance
(ProQuest Dissertations & Theses, 2008) -
Maternal vitamin D deficiency programs reproductive dysfunction in adult female mice offspring
(ProQuest Dissertations & Theses, 2016)Vitamin D is a fat soluble secosteroid produced in the endogenously skin, and is exogenously acquired from the diet. Vitamin D deficiency has reached near pandemic levels affecting over one billion people worldwide. This ... -
Maturation associated changes in glycoproteins from rat epididymal fluid and sperm membranes
(ProQuest Dissertations & Theses, 1989)A 32,000 dalton integral membrane glycoprotein can be labeled uniquely by galactose oxidase/ ({dollar}\sp3{dollar}H) sodium borohydride on the plasma of rat caudal, but not caput, epididymal sperm. Another glycoprotein of ... -
MEASLES VIRUS - PERSISTENT VIRAL INFECTIONS, ANTIGENIC VARIATION AND HUMAN DISEASE
(ProQuest Dissertations & Theses, 1982)Measles virus has been implicated in several chronic neurologic diseases of humans, i.e., subacute sclerosing panencephalitis (SSPE) and multiple sclerosis (MS). These diseases are thought to result from a persistent measles ... -
MEASLES VIRUS PERSISTENT INFECTION OF HUMAN LYMPHOBLASTOID CELLS
(ProQuest Dissertations & Theses, 1979) -
Mechanism and function of ZBP1 facilitated localization of beta-actin mRNA in neurons
(ProQuest Dissertations & Theses, 2002)The molecular mechanism of mRNA localization in neurons is not well understood. The objective of my thesis was to characterize the molecular mechanism of beta-actin mRNA localization in neurons and perturb it to assess ... -
Mechanism and Function Study of RpS12 Dependent Cell Competition
(ProQuest Dissertations & Theses Global, 2018)Cell competition is a phenomenon in which cells compete with each other based on their relative fitness within the same tissue. The ‘less-fit’ cells are by themselves viable but eliminated by other cells with better fitness ... -
Mechanism of action of antibody to capsular polysaccharide in Cryptococcus neoformans infection
(ProQuest Dissertations & Theses, 2002)Cryptococcus neoformans is an encapsulated fungus that causes meningoencephalitis in patients with AIDS. Several mAbs have been generated that bind the glucuronoxylomannan (GXM) component of cryptococcal polysaccharide ... -
Mechanism of Filovirus Entry: Disruption and Stabilization of the GP2 Post-Fusion Conformation
(ProQuest Dissertations & Theses, 2011)My thesis work focuses on the mechanisms that allow filoviruses to enter human cells. The Filoviridae family consists of both ebolaviruses and marburgviruses. In order for enveloped viruses to enter the cell, they must ... -
Mechanism of heavy chain class switch
(ProQuest Dissertations & Theses, 1989)During B cell development, successive DNA rearrangements assemble complete heavy and light chain antibody genes from component sequences present in multiple copies in the germline. Productive heavy chain variable region ... -
Mechanism of ligand-receptor interaction in yeast
(ProQuest Dissertations & Theses, 1995)A detailed biochemical characterization of the yeast {dollar}\alpha{dollar}-factor receptor was carried out in order to understand the mechanism of ligand/receptor interaction in yeast. The {dollar}\alpha{dollar}-factor ...