H/ACA ribonucleoproteins are small complexes of four conserved proteins and a small function defining RNA called the H/ACA RNA. Depending on the specific H/ACA RNA (out of the cellular pool of about 150 H/ACA RNAs) that ...

The near-infrared absorption band at about 760 nm (Band III) in hemeproteins is sensitive to the local heme conformation of equilibrium and nonequilibrium five coordinate ferrous high spin hemes. It is absent in six ...

Children infected by HIV-1 can demonstrate nervous system dysfunction. Because some HIV-1 positive children are believed to be infected during gestation and it is thought that HIV-1 may infect neural cells, the studies ...

The neuron is a powerful computational unit. However, neurons do not exist in isolation, rather they are embedded within intricate networks where each neuron is wired to tens of thousands of other neurons. Because of this ...

Neurochemical, behavioral, and pharmacological evidence indicates the existence of multiple opiate receptors and multiple opioid peptides of the central nervous system. Light microscopy auto-radiography studies have ...

The molecular pathogenesis underlying the selective neuronal subtype vulnerability to late-onset neurodegeneration in Huntington's disease (HD) remains elusive. Clarification of the underlying pathogenic mechanism(s) may ...

Episodic rhythmic behaviors stop, remain in quiescence, and restart. This stopping and restarting and the nature of the quiescent phase has been relatively less well explored than the mechanism of rhythm generation itself. ...

Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that predominantly affects women of color. About 20 to 40% of lupus patients suffer from diffuse neuropsychiatric manifestations of SLE (NPSLE), including ...

Toxoplasma gondii is an intracellular parasite. Each strain of the parasite has phenotypic differences relating to virulence, host preference, and competence for life cycle progression. Using high-throughput RNA sequencing, ...

The transmembrane receptor Notch and its ligand Delta are components of the highly conserved Notch signaling pathway that is required to regulate multiple developmental decisions. The most studied role of Notch is lateral ...