Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 960-979 of 1674
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Obesity-associated extracellular and ultrastructural changes in adipocytes: Impact on insulin sensitivity
(ProQuest Dissertations & Theses, 2009)Obesity is characterized by adipose tissue expansion due to excess caloric intake, which then leads to increased risk for the development of metabolic complications, such as Type 2 diabetes. Obesity-associated changes in ... -
Of man in mice: Human-mouse chimeras as in vivo model systems for studying human hematopoiesis, immunology and HIV infection
(ProQuest Dissertations & Theses, 1995)The overall goal of this thesis was the development of an animal model system that would permit the in vivo study of human hematopoiesis, immunology and infection with human specific pathogens such as HIV. To this end ... -
Of virus in mice: Defining transgenic mouse models for HIV-1 research
(ProQuest Dissertations & Theses, 2002)The pathogenesis of HIV-1 infection and the evaluation of therapeutics and vaccines can best be studied in vivo. Previously constructed mice were transgenic for expression of the cellular receptors for HIV-1, human CD4 and ... -
Oligomerization, assembly and entry of Semliki Forest virus spike protein mutants
(ProQuest Dissertations & Theses, 1994)The E1 and E2 spike protein subunits of Semliki Forest virus (SFV) form a heterodimeric complex. The dimer interaction is very important during membrane fusion and budding. Using an SFV infectious clone, we have characterized ... -
On Evolutionary Dynamics: Theory and Experiments
(ProQuest Dissertations & Theses Global, 2018)After the first life forms emerged, the primitive organization of these protobiotic systems must have imposed severe constraints in the metabolic networks that they were able to encode. A solid hypothetical candidate for ... -
ON THE MODE OF ACTION OF ACETYLCHOLINE ON THE ADRENAL MEDULLA
(ProQuest Dissertations & Theses, 1963) -
On the molecular mechanism of IL-4 immunosuppression and the characterization of NFIL-2B
(ProQuest Dissertations & Theses, 1993)IL-2 and IL-4 are lymphokines produced by different functional T-cell subsets, T{dollar}\sb{lcub}\rm H{rcub}{dollar}1 and T{dollar}\sb{lcub}\rm H{rcub}{dollar}2 respectively, and reciprocally negatively regulate each other. ... -
On the role of TRPM1 desensitization in retinal signaling
(ProQuest Dissertations & Theses, 2012)Studies of retinal ON bipolar cells (BCs) reveal that prolonged light stimulation triggers a Ca2+ dependent desensitization of the synaptic current mediated by Trpm1, whose conductance is negatively regulated by a metabotropic ... -
ONE-SIDED PORES FORMED BY NYSTATIN IN LIPID BILAYER MEMBRANES
(ProQuest Dissertations & Theses, 1984)The polyene antibiotic, nystatin, forms pores in eukaryotic cell membranes as well as in artificial membranes that contain sterol. In sterol-containing planar artificial bilayers, nystatin forms two types of pores. When ... -
OPIATE RECEPTORS AND THEIR INTERACTIONS WITH ADENYLATE CYCLASE IN MAMMALIAN BRAIN
(ProQuest Dissertations & Theses, 1982)Monkey amygdala was utilized to directly compare the interaction of opioid compounds with binding sites and with receptor-coupled adenylate cyclase (AC). AC activity of amygdala homogenates was doubled in the presence of ... -
Opioid receptor modulation by cannabinoids and receptor expression in culture
(ProQuest Dissertations & Theses, 1990)The existence of specific binding sites for opiate alkaloids in mammalian central nervous system was first reported more than 15 years ago. It is now generally accepted that the brain contains at least three distinct opioid ... -
OPTIMAL SMOOTHING OF POISSON DEGRADED NUCLEAR MEDICINE IMAGE DATA (PROCESSING)
(ProQuest Dissertations & Theses, 1984)The development of a method that removes Poisson noise from nuclear medicine studies will have significant impact on the quantitative analysis and clinical reliability of these data. The primary objective of the work ... -
Organization and evolution of low copy repeats (LCR) on chromosome 22q11
(ProQuest Dissertations & Theses, 2006)Chromosome 22q11 harbors low copy repeat sequences that can mediate deletions, duplications, and translocations. The eight low copy repeats on chromosome 22q11, LCR22s, contain genes and pseudogenes. There are four main ... -
Organization and expression of mouse repetitive DNA sequences
(ProQuest Dissertations & Theses, 1987)Interspersed repetitive DNA sequences comprise 10-30% of mammalian genomes. To understand what functions these sequences may have, the organization and expression of four non-Alu mouse repetitive DNA sequences families was ... -
Organization and regulation of Chinese hamster alpha(1,3)fucosyltransferase genes
(ProQuest Dissertations & Theses, 1998)Recognition of selectins by their ligands initiates leukocyte recruitment to sites of inflammation, and sialyl-Lewis X (sLe{dollar}\sp{lcub}\rm x{rcub}{dollar})-type structures serve as the indispensable glycan determinants ... -
ORGANIZATIONAL AND FUNCTIONAL ANALYSIS OF THE INTERSPERSED REPETITIVE DNA SEQUENCES FROM THE NEMATODE CAENORHABDITIS ELEGANS
(ProQuest Dissertations & Theses, 1986)The model system selected for this study is that of the free-living soil nematode Caenorhabditis elegans. The low complexity of the C. elegans genome provides the opportunity to study the organization, origins, and ... -
Ovarian steroid regulation of signal transduction by noradrenergic receptors
(ProQuest Dissertations & Theses, 1991)These experiments test the hypothesis that the ovarian hormones estradiol (E{dollar}\sb2{dollar}) and progesterone (P) regulate noradrenergic receptor responsiveness in neuronal populations which control reproduction, the ... -
Overexpression of Fyn inhibits macroautophagy while activating the mTORC1-IRE1a pathway leading to cell death
(ProQuest Dissertations & Theses, 2015)Skeletal muscle accounts for about 40% of total body weight in the human body. In addition to its function in whole body movements, skeletal muscle also plays an important role in the regulation of energy metabolism. ... -
Overexpression of nerve growth factor in the hearts of transgenic mice: Neural and cardiac consequences
(ProQuest Dissertations & Theses, 1996)Neurotrophins are an important class of structurally related proteins which play roles in both the developing and mature nervous system. Nerve growth factor (NGF), the prototypic member of the neutrophin family, was ... -
Overexpression, in vitro reconstitution, and crystal structures of two murine MHC class I-antigenic peptide complexes (H-2K(b) and D(b))
(ProQuest Dissertations & Theses, 1994)A key element in the cellular immune response resides in the ability of cytotoxic T cells to recognize MHC class I molecules with either foreign or self peptides bound in their antigen-binding grooves. Since it is extremely ...