Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 1084-1103 of 1674
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Quality control of a transcriptional regulator by SUMO-targeted degradation
(ProQuest Dissertations & Theses, 2009)MOT1 encodes an essential ATPase that functions as a general transcriptional regulator in vivo by modulating TATA-Binding Protein (TBP) DNA-binding activity. To better understand the role(s) of MOT1 in vivo, we selected ... -
Quantification and Characterization of the Nucleolar Channel System of Human Endometrium
(ProQuest Dissertations & Theses, 2013)Nucleolar channel systems (NCSs) are membranous structures discovered in 1960 with electron microscopy that are unique to the nuclei of endometrial epithelial cells (EECs). NCSs are now detected with indirect immunofluorescence ... -
Quantum mechanical studies of proton transfer in condensed phase
(ProQuest Dissertations & Theses, 2000)Theoretical studies of proton transfer in condensed phase are presented. Three particular issues have been addressed: the effect of anharmonicity of the bath modes, the role of coupled nonreactive motions in laser control ... -
RABBIT ERYTHROID RIBONUCLEASES
(ProQuest Dissertations & Theses, 1975) -
RADIOIMMUNOLOGICAL STUDIES OF THYMOSIN
(ProQuest Dissertations & Theses, 1974) -
Radioimmunotherapy and antiviral therapy: An elimination strategy for HIV-infected cells
(ProQuest Dissertations & Theses, 2015)While antiretroviral therapy (ART) has dramatically improved life expectancy for people infected with HIV/AIDS, it cannot kill infected cells. These cells persist in cellular and anatomical reservoirs, leading to disease ... -
Rat carboxypeptidase E gene: Structure, expression, and regulation of expression
(ProQuest Dissertations & Theses, 1993)The gene for rat carboxypeptidase E (CPE), a neuropeptide-processing enzyme, has been cloned and partially sequenced. The entire CPE gene spans 50 kilobases and consist of nine exons, each of which contains protein-coding ... -
RAT LIVER GLUTAMYL-RNA SYNTHETASE: PURIFICATION, PROPERTIES AND EFFECT OF POLYNUCLEOTIDES
(ProQuest Dissertations & Theses, 1966) -
Rational Protein Design to Dissect Class I Viral Fusion Mechanisms
(ProQuest Dissertations & Theses, 2014)Enveloped viruses utilize surface glycoproteins to facilitate membrane fusion with a host cell in order to deliver viral genetic material, a necessary early step in the infection process. In the case of class I viruses, ... -
Re-assessing the role of the floor plate as an intermediate target for commissural axons in the embryonic mouse spinal cord
(ProQuest Dissertations & Theses, 2006)In the developing nervous system, axons navigate great distances to reach their final targets. Along their path, they encounter intermediate targets, which contain cues to guide them along the next leg of their journey. ... -
REACTIONS OF ALPHA-HALO-ALPHA,ALPHA-DIHALO-AND ALPHA-MESYLOXYKETONES WITHPHOSPHINES
(ProQuest Dissertations & Theses, 1969) -
REACTIONS OF ALPHA-HALOKETONES WITH TERTIARY ORGANOPHOSPHORUS COMPOUNDS
(ProQuest Dissertations & Theses, 1970) -
Receptor editing in a mature, autoreactive B cell population
(ProQuest Dissertations & Theses, 2004)Anergy, clonal deletion, and receptor editing are important mechanisms in maintaining tolerance in the immature B cell repertoire. While the role of receptor editing is an accepted mechanism in the immature population, ... -
Recessive mutations that activate transcription by RNA polymerase III in Saccharomyces cerevisiae
(ProQuest Dissertations & Theses, 1996)Dominant and recessive mutations in the PCF1 gene, which encodes the 131 kDa subunit of transcription factor IIIC (TFIIIC{dollar}\sb{lcub}131{rcub}),{dollar} increase transcription by RNA polymerase III (pol III) in vivo ... -
Recombinant BCG vaccines for the prevention of cancer
(ProQuest Dissertations & Theses, 2000)The anti-tuberculosis vaccine bacille Calmette-Guerin (BCG) has been administered to more than 3 billion people worldwide. Aside from its use in tuberculosis and leprosy control, BCG has been well studied for its stimulation ... -
RECONSTITUTION OF PBR322 DNA REPLICATION IN VITRO WITH PURIFIED PROTEINS
(ProQuest Dissertations & Theses, 1985)The replication of a duplex, covalently-closed supercoiled (form I) DNA as an intact molecule requires that the topology of the DNA be modulated. The role of proteins that alter DNA structure, e.g., topoisomerases and ... -
Region specific histone modifications in class switch recombination
(ProQuest Dissertations & Theses, 2005)Class switch recombination (CSR) rearranges the antibody variable (V) region from mu to one of the downstream gamma, epsilon or alpha constant (C) regions in the immunoglobulin heavy chain locus, which results in the ... -
REGULATED EXPRESSION OF HUMAN GLOBIN GENES AND NEIGHBORING SEQUENCES INTRODUCED INTO ERYTHROID AND NONERYTHROID CELLS (ACTIVATION, DNA-MEDIATED TRANSFER, NEGATIVE REGULATION, CHROMATIN DOMAINS, TAP)
(ProQuest Dissertations & Theses, 1985)The regulation of human globin genes during hemopoietic differentiation was investigated by introducing these genes into mouse erythroleukemia (MEL) cells by chromosome transfer and by DNA-mediated gene transfer (DMGT). ... -
Regulation and functions of the drosophila ID protein extra macrochaetae in neural development
(ProQuest Dissertations & Theses, 2017)The well-conserved basic helix-loop-helix (bHLH) genes encode dimeric transcription factors essential for many developmental events. The activities of tissue-specific bHLH transcription factors require their heterodimerization ... -
REGULATION BY PHOSPHORYLATION OF CAMP-DEPENDENT PROTEIN KINASE FROM BOVINE CARDIAC MUSCLE
(ProQuest Dissertations & Theses, 1977)