In mammalian spermatozoa, most of the type II{dollar}\alpha{dollar} isoform of cAMP-dependent protein kinase (PKAII{dollar}\alpha{dollar}) is selectively anchored at the cytoplasmic surface of a specialized array of ...

Myofibroblasts are cells found in both normal and pathological states that have structural and functional features of both muscle and nonmuscle cells. The goal of this project was to determine how these cells achieve their ...

Sec7 GEFs are known to activate small G proteins of the ARF (ADP ribosylation factors) family, which act to regulate cellular functions such as vesicular trafficking, microtubule dynamics and development. In 1999, a guanine ...

Halobacterium halobium is a halophilic archaebacterium which has been intensively studied in recent years for a family of retinal-containing membrane proteins which are light-receptors for the primary energetic needs of ...

In order to define the sequence requirements of sarcomeric myosin thick filament assembly, a number of segments of a human adult fast skeletal myosin rod were expressed in Escherichia coli. The isolated proteins were ...

The aim of this thesis research is to characterize the human sarcomeric myosin heavy chain (MyHC) gene family. MyHCs are actin-based molecular motors that convert chemical energy released from the hydrolysis of ATP into ...

Myoclonus-dystonia syndrome (M-D) has been defined as an autosomal dominant disorder characterized by myoclonic jerks and dystonia that are often responsive to alcohol. In the majority of families, the disease has been ...

The short latency auditory evoked potentials (SLAEP), recorded during the first few milliseconds following a brief acoustic stimulus, are believed to originate in the subcortical structures of the auditory pathways. The ...

Time dependent physicochemical methods measure average solution properties. Electron microscopy (EM), however, reveals polydispersity in rod-like polymer systems through fiber lengths. The length of each fiber indicates ...