Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 1406-1425 of 1674
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T cell recognition of isocitrate lyase in host immunity to tuberculosis
(ProQuest Dissertations & Theses, 2007)Mycobacterium tuberculosis (MTB) is one of the world's most successful pathogens, infection two billion people and killing two million every year. The current vaccine, BCG, is of limited efficacy, and new vaccines are ... -
Targeted disruption of skeletal myosin heavy chain genes in the mouse
(ProQuest Dissertations & Theses, 1996)Skeletal myosin heavy-chain (MyHC) genes are part of a family of which there are seven known isoforms expressed in mammalian striated muscle. These include genes expressed in developing muscle (MyHC-emb, MyHC-pn), and those ... -
Targeted somatic hypermutation in cultured B cell lines
(ProQuest Dissertations & Theses, 2001)Using the NSO in vitro system that was established in our lab several years ago, we find that not only variable (V) regions of transfected Ig genes undergo relatively high rates of mutation, but that the constant (C) regions ... -
Targeting effector CD4 T cell developmental plasticity for improving vaccine design
(ProQuest Dissertations & Theses, 2013)Naive CD4 T cells have remarkable developmental plasticity and can differentiate into TH1, TH2, TH17, inducible regulatory T cells (iTreg), and T follicular helper cells (TfH) subsets, each capable of orchestrating a unique ... -
Targeting of intracellular signals by cAMP/PKA
(ProQuest Dissertations & Theses, 1996)A Kinase Anchor Proteins (AKAPs) bind and concentrate PKAII isoforms at several sites within mammalian cells. Little is known about the conservation of this mechanism of targeting signals carried by cAMP in lower organisms. ... -
Targeting of rotaviral glycoproteins to the endoplasmic reticulum
(ProQuest Dissertations & Theses, 1991)This dissertation utilizes the simian rotavirus SA11 as a model system to study the mechanism of retention of glycoproteins in the endoplasmic reticulum (ER). Rotavirus encodes two glycoproteins, VP7 and NS28, which are ... -
Targeting pyrimidine synthesis in Plasmodium falciparum with transition state analogues of orotate phosphoribosyltransferase
(ProQuest Dissertations & Theses, 2011)Orotate phosphoribosyltransferase (OPRT) catalyzes the reversible formation of orotidine 5'-monophosphate (OMP) from alpha-D-phosphoribosylpyrophosphate (PRPP) and orotate, the 5th step in de novo pyrimidine synthesis. ... -
Targeting TNF-a regulating genes to enhance tuberculosis vaccination
(ProQuest Dissertations & Theses, 2015)Tumor necrosis factor-a (TNF) plays a critical role in controlling the host immune response to tuberculosis. After exposure to Mycobacterium tuberculosis (MTB), TNF is essential for the formation and maintenance of the TB ... -
Taxol and discodermolide: Functional similarities and differences
(ProQuest Dissertations & Theses, 2001)Taxol is used successfully for the treatment of human breast, ovarian, and lung carcinomas. Taxol binds to the beta-tubulin subunit in the microtubule polymer and acts by stabilizing microtubules. Despite the success of ... -
Taxol: Mechanisms of action and resistance
(ProQuest Dissertations & Theses, 1998)Taxol is an antitumor agent that has been approved for the treatment of ovarian, breast and lung carcinomas. The major cellular target for Taxol is beta-tubulin. Taxol stabilizes microtubules leading to a mitotic block and ... -
TBX1 Preferentially Binds and Regulates Transcription of Downstream Targets Via a Tandem T-site Repeat
(ProQuest Dissertations & Theses, 2014)Haploinsufficiency of TBX1 is largely responsible for the etiology of physical malformations in individuals with velo-cardio-facial syndrome/DiGeorge syndrome/ 22q11 deletion syndrome. TBX1 encodes a transcription factor ... -
TEMPERATURE SENSITIVE MITOCHONDRIALLY INHERITED MUTATIONS OF BAKER'S YEAST
(ProQuest Dissertations & Theses, 1978) -
TEMPORAL AND SPATIAL CONTROL OF A CAULOBACTER CRESCENTUS FLAGELLAR PROTEIN
(ProQuest Dissertations & Theses, 1987)Caulobacter crescentus synthesizes a single polar flagellum at a specific time in its cell cycle. The synthesis and assembly of the flagellum, as well as the chemotaxis machinery, depends on a complex regulatory cascade ... -
TGF-beta is a common mediator for podocyte differentiation and apoptosis
(ProQuest Dissertations & Theses, 2006)Podocytes, highly specialized cells in the kidney which regulate plasma filtration, are often injured and lost in glomerular disease. The underlying mechanisms for growth-arrest, differentiation, and depletion of podocytes ... -
The actions of polyamines on NMDA receptors: Electrophysiological and molecular studies
(ProQuest Dissertations & Theses, 1997)Polyamines such as spermine regulate the activity of many neuronal channels, including both non-NMDA and NMDA glutamate receptors. Because of the fundamental role of NMDA receptors in brain function, it is important to ... -
THE ACTIVE SITE OF RABBIT LIVER ALDOLASE
(ProQuest Dissertations & Theses, 1967) -
The adipocyte as an integral stromal contributor to mammary tumor development
(ProQuest Dissertations & Theses, 2005)Mammary epithelial cells are embedded in a unique extracellular environment. Adipocytes are an integral part of this stromal microenvironment. Mammary epithelial cells are critically dependent on this milieu for survival. ... -
The adult fast myosin heavy chains isoforms: Studies in development and consequences of gene disruption
(ProQuest Dissertations & Theses, 2000)Voluntary movements of vertebrates are created by the specialized tissue of skeletal muscle. To produce movement, chemical energy stored in ATP is converted into mechanical force by the Myosin Heavy Chain (MyHC) protein. ... -
The alpha and beta cardiac myosin heavy chain isoforms direct mutation-specific effects on myofilament activation in Troponin-T related cardiomyopathies in vivo
(ProQuest Dissertations & Theses, 2009)Myofilament activation couples myocellular Ca2+ rise to thin filament sliding. Within the sarcomere, Troponin-T plays a central role in myofilament activation. Naturally occurring mutations of Troponin-T impair activation ... -
THE ALPHA-GLOBIN GENES ARE LOCATED IN A REGION OF EARLY-REPLICATING DNA IN FRIEND ERYTHROLEUKEMIA CELLS
(ProQuest Dissertations & Theses, 1980)The time of replication in the S phase of regions of the mouse genome including the (alpha)-globin genes was determined in the Friend virus-transformed murine erythroleukemia cell line. Cells grown for short times in the ...