Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 1653-1672 of 1674
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Uncovering the heparan sulfate domain topography of C. elegans using a novel heparan sulfate domain visualization system
(ProQuest Dissertations & Theses, 2014)Heparan sulfate (HS) is a long, linear glycosaminoglycan (GAG) attached to core proteins forming extracellular HS proteoglycans. HS domains are stretches of modification patterns encoded onto HS GAGs by HS modifying enzymes ... -
Understanding the Role of Macrophage-Tumor Cell Interaction in Breast Cancer Progression
(ProQuest Dissertations & Theses Global, 2018)While monocyte/macrophages are essential components of innate immunity, they can also have deleterious effects to the host in pathological conditions such as chronic inflammatory diseases or cancer. Tumor-associated ... -
Unraveling the mechanism of diabetes resistance in GLUT4 knockout mice
(ProQuest Dissertations & Theses, 2004)Using homologous recombination and embryonic stem cell technology, Katz et al. (1995) generated global GLUT4 knockout mice (GLUT4 Null). Surprisingly these mice maintain normal fed and fasted glucose levels. This led us ... -
Unraveling the neural substrates of Rapid Onset Dystonia Parkinsonism
(ProQuest Dissertations & Theses, 2009)Rapid Onset Dystonia Parkinsonism (RDP) is an inherited autosomal dominant movement disorder characterized by the rapid onset of combined dystonia and parkinsonism. The symptoms include limb and cranial dystonic spasms, ... -
UNUSUAL LINKAGES IN COLLAGEN
(ProQuest Dissertations & Theses, 1962) -
Use of a defective herpes simplex virus for transfer of neurotrophin genes into cells of the nervous system
(ProQuest Dissertations & Theses, 1996)There is a need in neurobiology for an efficient method of transferring genes into cells of the nervous system in order to study the function of neuronal proteins, to create animal models of human disease, and to administer ... -
Use of in vitro mutants of H-2 in studying structure-function relationships
(ProQuest Dissertations & Theses, 1989)In these studies, in vitro mutants of the murine Major Histocompatibility Complex (MHC) class I H-2K{dollar}\sp{lcub}\rm b{rcub}{dollar} molecule were used to define some of the structural requirements for normal transport ... -
Use of retroviral integration to study evolution and cancer
(ProQuest Dissertations & Theses, 2002)Somatic infection by retroviruses can cause neoplastic disease if proviral formation results in alteration of the expression of a cellular cancer gene. Alternatively, if a retrovirus infects the host germline, it can be ... -
Using enhanced sampling molecular dynamics simulations to investigate the roles of disordered regions in proteins
(ProQuest Dissertations & Theses, 2016)Numerous proteins in the cell are intrinsically disordered proteins (IDPs), and even many structured proteins contain disordered regions that mediate important physiological functions. In this thesis, we explore two protein ... -
Using genetic markers to establish in vivo roles for Robo receptors in commissural axon guidance within the chick spinal cord
(ProQuest Dissertations & Theses, 2009)As axons grow in the developing embryo, they encounter intermediate targets along the way that break up their journey into short segments, which they navigate sequentially to ultimately reach their synaptic targets. These ... -
Using RNA as a tool to modify lipid nanoparticles
(ProQuest Dissertations & Theses, 2015)Lipid nanoparticles (LNPs) provide an attractive option for therapeutic applications because they can self-assemble and carry a diverse set of cargoes ranging from hydrophobic drugs to small interfering RNA (siRNA). Liposomes ... -
Utilizing adenoviral E3 immunomodulatory genes for prevention of hepatocellular allograft rejection
(ProQuest Dissertations & Theses, 2006)Hepatocyte transplantation is being explored as a life-saving treatment for patients with inherited liver diseases and liver failure. However, allograft rejection remains a major obstacle. Availability of genetically ... -
Variation of HERV-K content and expression in humans: Evolution, cancer, and irradiation
(ProQuest Dissertations & Theses, 2013)Ionizing Radiation (IR) has been shown to increase the immunogenicity of cancer cells in vitro and in vivo. IR has been reported to increase the transcriptional activity of many viruses in infected cells. We hypothesized ... -
VEGF-mediated actin dynamics in endothelial cells
(ProQuest Dissertations & Theses, 2007)The angiogenic growth factor Vascular Endothelial Growth Factor (VEGF)-mediated endothelial cell migration is an essential process in tumor angiogenesis. Actin reorganization is necessary for cell migration. My research ... -
Vesicular trafficking in hepatocytes: Roles of motor and Rab GTPases in endocytic vesicle processing
(ProQuest Dissertations & Theses, 2004)Hepatocytes take up the desialylated glycoprotein asialoorosomucoid (ASOR) through receptor-mediated endocytosis via the asialoglycoprotein receptor (ASGPR). ASOR and ASGPR dissociate from each other within early endocytic ... -
VIRAL CODED PROTEINS INVOLVED IN ADENOVIRUS DNA REPLICATION (TEMPERATURE SENSITIVE MUTANTS)
(ProQuest Dissertations & Theses, 1984)The adenovirus (Ad) in vitro DNA replication system provided a means for biochemical and genetic analysis of the Ad DNA-negative temperature sensitive (ts) mutants H5ts125, H5ts107 and H5ts149. Ad DNA synthesis was assayed ... -
VIRAL RNA EXPRESSION IN FRIEND VIRUS-INDUCED ERYTHROLEUKEMIA CELL LINES
(ProQuest Dissertations & Theses, 1980)Friend erythroleukemia virus (FV) consists of a complex of two distinct viruses, both classified as retroviruses because they contain RNA-dependent DNA polymerase (reverse transcriptase). The two viral components of FV are ... -
VOLTAGE DEPENDENT CONDUCTANCE INDUCED IN THIN LIPID MEMBRANES BY MONAZOMYCIN OR THE INTERACTION OF USELESS ANTIBIOTIC WITH FAT
(ProQuest Dissertations & Theses, 1971) -
VOLTAGE-DEPENDENT CHANNELS FORMED BY COLICINS
(ProQuest Dissertations & Theses, 1982)The bactericidal action of colicins K, E1, Ia and other functionally related colicins involves disruption of active transport and leakage of ions from the cell. I show that a single colicin molecule can form a voltage-dependent, ... -
X-LINKED CONTROL OF HEMOGLOBIN PRODUCTION IN SOMATIC CELL HYBRIDS
(ProQuest Dissertations & Theses, 1978)