Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 1064-1083 of 1673
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Protein-DNA interactions at the bacteriophage phi-X174 origin of replication
(ProQuest Dissertations & Theses, 1989)The gene A protein of bacteriophage {dollar}\phi{dollar}X174 is a site-specific endonuclease-ligase required for the synthesis of {dollar}\phi{dollar}X single-strand circular (SS(c)) DNA from supercoiled {dollar}\phi{dollar}X ... -
Proteolytic disassembly of the ebolavirus glycoprotein in viral entry
(ProQuest Dissertations & Theses, 2011)Ebolaviruses are enveloped, negative-sense, single-stranded RNA viruses that can cause a deadly hemorrhagic fever with case fatality rates as high as 90%. Like other enveloped viruses, ebolavirus enters cells by fusing its ... -
Proteomics, drugs and nonlytic exocytosis: The pursuit of novel therapies against Cryptococcus neoformans
(ProQuest Dissertations & Theses, 2017)Cryptococcus neoformans is an opportunistic fungal pathogen found worldwide that causes cryptococcosis, a potentially life-threatening disease in immunocompromised individuals. To gain insight into novel therapeutic targets, ... -
Proximal control of inducible nitric oxide synthase
(ProQuest Dissertations & Theses, 2010)Inducible Nitric Oxide Synthase (iNOS) catalyzes the formation of nitric oxide (NO) via a two step monooxygenation from Arginine to hydroxy-Arginine (NOHA), then to Citrulline and NO. The importance of NO in normal physiology ... -
PTP1B inhibition, catalysis, and physiological substrate
(ProQuest Dissertations & Theses, 2008)Protein-tyrosine phosphatases (PTPs) consist of over a hundred of enzymes that are important for the control of proper cellular tyrosine phosphorylation. Despite the emerging roles played by PTPs in human diseases, a ... -
PTP1B: Studies of its substrate specificity and an investigation into rational drug design
(ProQuest Dissertations & Theses, 2001)The regulation of cellular signaling processes is paramount for the maintenance of cellular homeostasis. Phosphorylation is one component of the signaling apparatus utilized by cells for the regulation of such cellular ... -
PURIFICATION AND CHARACTERIZATION OF A PROTEIN FACTOR FROM CALF LIVER EXTRACTS THAT PREVENTS REASSOCIATION OF EUKARYOTIC RIBOSOMAL SUBUNITS
(ProQuest Dissertations & Theses, 1981)A protein factor that prevents the reassociation of eukaryotic 40S and 60S ribosomal subunits when the Mg('2+) concentration is raised from 1 mM to 5 mM has been purified to apparent electrophoretic homogeneity from ... -
PURIFICATION AND CHARACTERIZATION OF A VIRUS SPECIFIED PROTEIN KINASE
(ProQuest Dissertations & Theses, 1977) -
PURIFICATION AND CHARACTERIZATION OF BEEF BRAIN HEXOKINASE
(ProQuest Dissertations & Theses, 1964) -
PURIFICATION AND CHARACTERIZATION OF ENZYMES INVOLVED IN TRANSCRIPTION AND PROCESSING OF VACCINIA VIRUS RNA
(ProQuest Dissertations & Theses, 1979) -
PURIFICATION AND CHARACTERIZATION OF HYDROXYINDOLE OXIDASE FROM GILL PLATES OF MYTILUS EDULIS
(ProQuest Dissertations & Theses, 1979) -
PURIFICATION AND CHARACTERIZATION OF SPINACH FRUCTOSE DIPHOSPHATE ALDOLASE
(ProQuest Dissertations & Theses, 1970) -
PURIFICATION AND PROPERTIES OF PHOSPHOPROTEIN PHOSPHATASES FROM BOVINE CARDIAC MUSCLE
(ProQuest Dissertations & Theses, 1979) -
PURIFICATION AND REGULATION OF THE F PLASMID TRAJ PROTEIN OF ESCHERICHIA COLI K-12 (CONJUGATION)
(ProQuest Dissertations & Theses, 1986)The TraJ protein encoded by the conjugative plasmid F is required for transcription of the other F plasmid transfer (tra) genes, and hence for conjugal DNA donor activity and surface exclusion of F' and Hfr strains of E. ... -
PURIFICATION AND SUBUNIT ANALYSIS OF EXONUCLEASE VII OF E. COLI; ISOLATION OF NEGATIVE-XSEB STRAINS AND LAMBDA-DXSEA TRANSDUCING PHAGE
(ProQuest Dissertations & Theses, 1982)Exonuclease VII, isolated from Escherichia coli, has been purified to 87% homogeneity. The protein is composed of two non-identical subunits of 54,000 and 10,500 molecular weights as shown by restoration of exonuclease VII ... -
Purification, cloning and expression of a signal transducer for sensory rhodopsin I in Halobacterium salinarium
(ProQuest Dissertations & Theses, 1993)Sensory rhodopsin I (SR-I) is a retinylidene integral membrane protein that functions as a photoreceptor in the archaeon, Halobacterium salinarium. SR-I modulates the frequency of swimming direction reorientation allowing ... -
Purine salvage as an antimalarial target
(ProQuest Dissertations & Theses, 2011)The members of the genus Plasmodia, which are the causative agents of malaria, lack the de novo purine synthesis machinery. It has been repeatedly demonstrated that these parasites rely on the salvage of hypoxanthine ... -
Purinergic receptors are required for HIV-1 infection of primary human macrophages
(ProQuest Dissertations & Theses, 2011)Macrophages are critical mediators of disease throughout the course of HIV infection. They are one of the first cells to become infected and they act as significant viral reservoirs. HIV enters macrophages through binding ... -
Purinergic signaling and the p75 tumor necrosis factor-alpha receptor critically regulate mechanisms of resistance to M. tuberculosis
(ProQuest Dissertations & Theses, 2000)Intracellular pathogens, such as M. tuberculosis , have developed strategies for subverting microbicidal mechanisms and living within the host macrophage. However, a variety of signals, such as those mediated by the cytokines ... -
Quality control of a transcriptional regulator by SUMO-targeted degradation
(ProQuest Dissertations & Theses, 2009)MOT1 encodes an essential ATPase that functions as a general transcriptional regulator in vivo by modulating TATA-Binding Protein (TBP) DNA-binding activity. To better understand the role(s) of MOT1 in vivo, we selected ...