Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 1104-1123 of 1673
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Regulation of actin polymerization during tumor cell invasion
(ProQuest Dissertations & Theses, 2009)Tumor metastasis, the spread of cancer from a primary site to a distant organ, is the leading cause of mortality among cancer patients. For a carcinoma cell to metastasize, it must first successfully invade the basement ... -
Regulation of anti -dsDNA B lymphocytes in autoimmunity: Molecular mimicry and hormone modulation of tolerance
(ProQuest Dissertations & Theses, 2003)Anti-double stranded (ds) DNA antibodies are responsible for much of the pathology of systemic lupus erythematosus. Two mouse models in which anti-dsDNA B cells escape tolerance were used to study their regulation.;A peptide ... -
Regulation of astrocyte activation in inflammation: Roles of interferon-beta and mitogen -activated protein kinases
(ProQuest Dissertations & Theses, 2001)Understanding the regulation of inducible nitric oxide synthase (NOS) and cytokine (TNFalpha and IL-6) expression in glia is of great importance because of the critical roles these factors play in CNS inflammation. In ... -
Regulation of autoreactive B cells in the non-autoimmune R4A -IgG2b transgenic mouse model, and, The role of estrogen in the immune system regulation
(ProQuest Dissertations & Theses, 1999)Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the presence of high titers of anti-double-stranded (ds) DNA antibodies in the serum of SLE patients and in SLE-prone mice strains; and ... -
Regulation of BCL6 expression in B cell development and lymphomagenesis
(ProQuest Dissertations & Theses, 2006)BCL6 is the most frequently translocated proto-oncogene in diffuse large B cell lymphomas (DLBCLs). It encodes a potent transcription repressor that is specifically expressed and critically required at the germinal center ... -
Regulation of central carbon metabolism in mycobacterium tuberculosis
(ProQuest Dissertations & Theses, 2015)Mycobacterium tuberculosis is the causative agent of tuberculosis, a disease that affects one third of the world's population and results in the death 1.5 million people a year. It is believed that M tuberculosis requires ... -
Regulation of chaperone-mediated autophagy
(ProQuest Dissertations & Theses, 2009)Autophagy, the turnover of intracellular components in lysosomes, is critical for maintaining cellular homeostasis. We have focused on chaperone-mediated autophagy (CMA), a selective type of autophagy. CMA activity is ... -
REGULATION OF CYCLIC-AMP - DEPENDENT PROTEIN KINASE SUBUNIT LEVELS IN FRIEND ERYTHROLEUKEMIC CELLS (DIFFERENTIATION, PHOSPHORYLATION)
(ProQuest Dissertations & Theses, 1985)Cytosolic extracts of Friend erythroleukemic cells contain both type I and type II cAMP-dependent protein kinases. In control cells the regulatory subunits of the type I and type II protein kinases (R I and R II) were ... -
Regulation of differentiation and gene expression in epithelial cells by cues from the cellular environment
(ProQuest Dissertations & Theses, 1995)In Part 1, a new model system of hepatocyte differentiation was characterized, and environmental factors influencing hepatic differentiation were investigated. Cell line L2039 was derived from E14 fetal mouse liver by ... -
REGULATION OF ENDOGENOUS AND TRANSFECTED HISTONE GENES IN MAMMALIAN CELLS (CYCLE, MOLECULAR BIOLOGY, TRANSFER)
(ProQuest Dissertations & Theses, 1984)The histones are a group of small basic proteins found in the eukaryotic cell nucleus. They appear to be synthesized only during periods of DNA replication. The mechanisms responsible for the periodic accumulation and decay ... -
REGULATION OF EXPRESSION OF MULTIPLY-INTEGRATED MOLONEY-MSV PROVIRAL SEQUENCES
(ProQuest Dissertations & Theses, 1983)A series of morphological revertants of a Moloney murine sarcoma virus-transformed NRK nonproducer line, 6 O('+)H('-), was analyzed. The 6 O('+)H('-) genome contains three complete stably integrated proviruses. Thus reversion ... -
REGULATION OF FATTY ACID SYNTHETASE DURING ADIPOCYTE DIFFERENTIATION: STUDIES ON 3T3-L1 CELLS
(ProQuest Dissertations & Theses, 1982)The activity, content, and turnover of the key lipogenic enzyme fatty acid synthetase were studied during the differentiation of 3T3-L1 preadipocytes into adipocytes. Cells were induced to differentiate by treatment with ... -
Regulation of gap junctions
(ProQuest Dissertations & Theses, 1993)Gap junctions are composed of intercellular channels that allow for electrotonic and metabolic coupling between adjacent cells. Each channel is an oligomeric assembly of homologous proteins, called connexins (Cxs), which ... -
Regulation of GTP hydrolysis during translation initiation in eukaryotes
(ProQuest Dissertations & Theses, 2005)In eukaryotes, AUG is the most preferred codon for translation initiation. This is in contrast to prokaryotes where non-AUG codons such as GUG or UUG codons can also be used for translation initiation. How this stringency ... -
Regulation of hematopoiesis by Smad1
(ProQuest Dissertations & Theses, 2006)The hematopoietic system develops in two distinct yet overlapping phases termed primitive (or embryonic) and definitive (or adult) hematopoiesis, which collectively supply the embryo and later the adult with a replenishing ... -
Regulation of HERG channel bio-processing
(ProQuest Dissertations & Theses, 2011)The long QT syndrome (LQTS) is a common cardiac disorder with potentially lethal consequences. While mostly asymptomatic, LQTS patients may develop Torsade de Pointes (TdP) arrhythmia, which can proceed into ventricular ... -
Regulation of Histone Chaperones by Intrinsically Disordered Regions and Acidic Stretches
(ProQuest Dissertations & Theses Global, 2018)The nucleosome is the fundamental repeating unit of chromatin that is responsible for the condensation of a large amount of genetic information into the nucleus as well as regulating gene expression. Nucleosomes are composed ... -
Regulation of histone modifications and cryptic transcription by the Bur1 kinase
(ProQuest Dissertations & Theses, 2008)RNA polymerase II-directed transcription is a complex process, which occurs in the context of chromatin. To understand how transcription elongation factors are involved in transcription regulation in the context of chromatin, ... -
Regulation of inflammation in the central nervous system by interleukin-1 and transforming growth factor-beta-1
(ProQuest Dissertations & Theses, 1996)Inflammation within the central nervous system (CNS) results in significant pathology and is controlled by properties of the blood-brain-barrier (BBB). We developed an animal model of retinal inflammation in the rabbit ... -
REGULATION OF INOSITOL BIOSYNTHESIS IN SACCHAROMYCES CEREVISIAE
(ProQuest Dissertations & Theses, 1975)