Malignant transformation of animal cells in vitro involves changes in many cellular properties, but most of these can be dissociated from malignant growth potential in vivo. Earlier studies showed that anchorage independent ...

The B7 ligand and CD28 receptor family of proteins are critical in the maintenance of normal immune homeostasis, specifically with regard to T cells. The ligation between B7 ligands and its corresponding CD28 receptor(s) ...

Heparan sulfate (HS) is a long, linear glycosaminoglycan (GAG) attached to core proteins forming extracellular HS proteoglycans. HS domains are stretches of modification patterns encoded onto HS GAGs by HS modifying enzymes ...

Using homologous recombination and embryonic stem cell technology, Katz et al. (1995) generated global GLUT4 knockout mice (GLUT4 Null). Surprisingly these mice maintain normal fed and fasted glucose levels. This led us ...

In these studies, in vitro mutants of the murine Major Histocompatibility Complex (MHC) class I H-2K{dollar}\sp{lcub}\rm b{rcub}{dollar} molecule were used to define some of the structural requirements for normal transport ...

Numerous proteins in the cell are intrinsically disordered proteins (IDPs), and even many structured proteins contain disordered regions that mediate important physiological functions. In this thesis, we explore two protein ...

Lipid nanoparticles (LNPs) provide an attractive option for therapeutic applications because they can self-assemble and carry a diverse set of cargoes ranging from hydrophobic drugs to small interfering RNA (siRNA). Liposomes ...

Ionizing Radiation (IR) has been shown to increase the immunogenicity of cancer cells in vitro and in vivo. IR has been reported to increase the transcriptional activity of many viruses in infected cells. We hypothesized ...