In this thesis, the role of the bisecting GlcNAc of complex N-glycans was investigated during hepatocarcinogenesis and liver regeneration after partial hepatectomy (PH). The bisecting GlcNAc is transferred to N-glycans ...

There is widespread interest in the relationship between aging and cancer, and the involvement of senescence in both processes. A growing body of evidence indicates that senescent cells impart elevated risk of age-associated ...

Familial Hypertrophic Cardiomyopathy (FHC) is one of the most frequently occurring cardiac genetic disorders and a common cause of sudden cardiac death in young people. The majority of FHC mutations in the thin filament ...

Gap junctions are intercellular channels that allow the direct transmission of ions, second messengers, and cellular metabolites between coupled cells. Connexin (Cx) genes encode gap junction proteins. The precise molecular ...

Gap junctions have been identified as the conduit for electrical and metabolic coupling between adjacent cells providing modifiable cytoplasmic continuity. Gap junctions consist of subunits called connexins which are members ...

A biochemical, molecular and genetic analysis of the S. cerevisiae INO1 gene and its product, MI-1-P synthase has provided, for the first time, a physical basis for the organization of the INO1 locus and regulation of its ...

Colony stimulating factor-1 (CSF-1) is a homodimeric glycoprotein that humorally regulates the proliferation and differentiation of mononuclear phagocytic cells and locally regulates cells of the female reproductive tract. ...

Primitive erythrocytes are the first red blood cells to form in the embryo. The lineage is transient and produces nucleated cells that express embryonic globins distinct from adult (definitive) erythrocytes. The molecular ...

Here I report that the heavy chains of both botulinum and tetanus toxins form channels in planar bilayer membranes. These channels have pH and voltage-dependent properties remarkably similar to those of the diphtheria toxin ...