Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 21-40 of 1674
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A MORPHOPHYSIOLOGICAL STUDY OF THE SUPERIOR VESTIBULAR NUCLEUS IN THE CAT
(ProQuest Dissertations & Theses, 1981)The present study is an attempt to increase the understanding of the role of the superior vestibular nucleus (SVN) in the vestibulooclar reflex (VOR) and, in general, in the control of gaze by brain stem neurons. The prime ... -
A multipronged mechanistic study of the sodium iodide symporter (NIS): Subcellular localization, stoichiometry, transport of the environmental pollutant perchlorate, and purification for structural analysis
(ProQuest Dissertations & Theses, 2011)Iodide (I-) transport in the thyroid, the rate-limiting step in thyroid hormone biosynthesis, is mediated by the Na+/I - symporter (NIS). NIS also mediates I- transport in other polarized epithelia, where NIS is localized ... -
A Naturally occurring polymorphism in the HIV-1 Tat protein basic domain modulates its uptake by bystander cells and their subsequent inflammatory output
(ProQuest Dissertations & Theses, 2016)HIV-infected cells can reach the central nervous system (CNS) and release HIV virions, which productively infect macrophages and microglia. Infected cells release both viral and host factors that can induce inflammation ... -
A neural code for sensory reliability in the sound localization system of the barn owl
(ProQuest Dissertations & Theses, 2016)Imprecision of sensory information is inherent in the physical nature of stimuli and sensory organs. To handle the uncertainty associated with sensory stimuli that are noisy and ambiguous, our brain must evaluate the level ... -
A neuroanatomical analysis of striosome-matrix compartmentalization and motor deficits in YAC mouse models of Huntington's disease
(ProQuest Dissertations & Theses, 2009)The striatum contains mu opioid receptor-rich (MOR) cells called striosomes embedded in an extrastriosomal matrix. In Huntington's disease (HD), the striosomes and matrix may be differentially targeted and contribute to ... -
A NEURONAL ANTIGEN IN THE BRAINS OF ALZHEIMER PATIENTS
(ProQuest Dissertations & Theses, 1987)The material presented herein describes the production and study of a monoclonal antibody, Alz-50, that recognizes an antigen, A68, which accumulates in the brains of individuals who have Alzheimer's desease. Alz-50 was ... -
A new humanized mouse model for studying HIV infection and antiretroviral therapeutics and human hematopoietic stem cell-delivered gene therapy to generate anti-HIV cytotoxic T cells
(ProQuest Dissertations & Theses, 2010)In recent years, humanized Rag2-/-gammac -/- mice have emerged as a potential model for studying HIV infection and immune responses in vivo. These mice support the in vivo maturation of human hematopoietic stem cells into ... -
A novel 3' IgH enhancer element regulated at multiple stages of B cell development
(ProQuest Dissertations & Theses, 1996)Multiple cis-acting elements are involved in the regulation of IgH gene expression and rearrangement events, including the intronic enhancer, E{dollar}\mu,{dollar} and a complex regulatory region located downstream of the ... -
A novel mechanism for rescuing autoreactive B cells generated in vivo by somatic mutation
(ProQuest Dissertations & Theses, 1996)The ultimate success of the immune system resides in its ability to discriminate between small molecular differences that distinguish foreign from self epitopes. This is a daunting task when one considers the magnitude of ... -
A novel mouse model of dementia implicates beta-secretase, Thr668 of APP, and Tau in the pathogenesis of Alzheimer's Disease
(ProQuest Dissertations & Theses, 2013)Familial Alzheimer's disease (AD), Danish (FDD) and British Dementias (FBD) are autosomal dominant diseases defined by the presence of neurodegeneration, extra cellular amyloid plaques, and intracellular neurofibrillary ... -
A novel regulator of the synthesis of complex and hybrid N-glycans
(ProQuest Dissertations & Theses, 2010)Protein N-glycosylation affects many biological functions of glycoconjugates in development and disease. It occurs in the endoplasmic reticulum (ER) and Golgi compartments, and is catalyzed by resident glycosyltransferases ... -
A novel role for clathrin in mediating assembly of the Golgi apparatus
(ProQuest Dissertations & Theses, 2006)The Golgi apparatus is the central processing and sorting station for lipids and proteins in the secretory pathway and it consists of a network of stacked, specialized cisternae localized to the perinuclear region of the ... -
A novel role for the apoptosis inhibitor ARC in suppressing death receptor-mediated necrosis
(ProQuest Dissertations & Theses, 2013)Apoptosis and necrosis are two morphologically distinct forms of cell death that have been described. Apoptosis has long been recognized as a form of regulated cell death. In contrast, necrosis has traditionally been viewed ... -
A novel testicular Mu class GST subfamily
(ProQuest Dissertations & Theses, 1997)Glutathione S-transferases (GSTs) are a family of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophiles, and also function as lipophilic binding proteins. Although one Pi class, five ... -
A novel transcriptional network of broadly expressed HLH genes: Regulating tissue specific cell fates
(ProQuest Dissertations & Theses, 2011)Neural patterning is attributed to highly regulated transcription of specific proneural bHLH transcription factors (Scute, Achaete, Atonal in Drosophila and their homologs Mash, Math, Neurogenins etc.) that define neuronal ... -
A nuclease from Drosophila and rRNA processing in yeast: Part~I. Nuclease III from adult flies of Drosophila melanogaster. Part~II. Mutants involved in pre- rRNA processing in Saccharomyces cerevisiae
(ProQuest Dissertations & Theses, 1990)Part I. An endo-exonuclease (designated nuclease III) has been purified to virtual homogeneity from adult flies of Drosophila melanogaster. The enzyme degrades single- and double-stranded DNA and RNA. It has a sedimentation ... -
A PHOSPHORUS NMR STUDY OF E. COLI ALKALINE PHOSPHATASE
(ProQuest Dissertations & Theses, 1976) -
A program evaluation of the Caregiver Assistance Program
(ProQuest Dissertations & Theses, 2002)The Caregiver Assistance Program (CAP) of North Broward Medical Center in Pompano Beach, Florida is a training and education program targeted towards dementia caregivers and taught in a multi-disciplinary approach. Responding ... -
A PROTON MAGNETIC RESONANCE (PMR) STUDY OF CARBONIC ANHYDRASE
(ProQuest Dissertations & Theses, 1974) -
A PS1 mutation linked to familial Alzheimer's disease induces neurodevelopmental abnormalities in forebrain
(ProQuest Dissertations & Theses, 2010)Alzheimer's disease (AD) is a devastating condition that accounts for the majority of dementia cases. However, the precise temporal and spatial evolution of neuropathological alterations remains unresolved. Studies examining ...