Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 359-378 of 1673
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DEVELOPMENT OF METHODS USING CARBON-14 LABELED CYANIDE FOR THE STUDY OF CROSSLINKING IN COLLAGEN AND ELASTIN
(ProQuest Dissertations & Theses, 1975) -
Development of mouse models to delineate the tumour suppressor function of INI1/hSNF5 gene
(ProQuest Dissertations & Theses, 2003)Studies in our laboratory have demonstrated that re-introduction of INI1/hSNF5 gene back to INI1-/- cell lines derived from human MRT causes G0/G1 arrest and that this arrest is correlated with the ability of INI1/hSNF5 ... -
Development of systems for the genetic study of mycobacteria: Towards a recombinant BCG multivaccine
(ProQuest Dissertations & Theses, 1990)Tuberculosis and leprosy continue to inflict disease and death upon millions of people, primarily in the developing world. A significant increase in mycobacterial infections worldwide has been associated with the AIDS ... -
Development of targeted therapies for rhabdoid tumors based on the function of INI1 as a tumor suppressor
(ProQuest Dissertations & Theses, 2011)Rhabdoid tumors (RTs) are aggressive pediatric malignancies characterized by loss/inactivation of the INI1 tumor suppressor. Current treatments for RTs are rarely curative. Thus, our goals involved further understanding ... -
DEVELOPMENT OF THE SYMPATHETIC GANGLIA IN THE MEXICAN AXOLOTL, AMBYSTOMA MEXICANUM
(ProQuest Dissertations & Theses, 1976) -
Development of transgenic mouse models to study HIV -1 replication
(ProQuest Dissertations & Theses, 2000)Efficient HIV-1 replication in mice is limited by their lack of human-restricted HIV-1 receptors and co-factors required for HIV-1 replication. The goal of this thesis was to use a transgenic approach to delineate the ... -
DEVELOPMENTAL ANALYSIS OF TWO EMBRYONIC LETHAL ALLELES IN THE MOUSE
(ProQuest Dissertations & Theses, 1976) -
Developmental control of chromatin at the 3' end of the Igh locus
(ProQuest Dissertations & Theses, 2004)The Igh locus is subject to many processes that occur during B-cell development, including V(D)J recombination, class switching, and somatic hypermutation. The murine Igh locus has a 3 ' regulatory region (3' RR), containing ... -
Developmental control of peripheral sense organs in Caenorhabditis elegans by a transcription factor of thebHLH family
(ProQuest Dissertations & Theses, 1995)The nematode Caenorhabditis elegans is an excellent model system for the study of cell fate determination. The complete cell lineage of this organism has been elucidated, which reveals the developmental origins of all ... -
DEVELOPMENTAL GENETICS OF A LETHAL MUTATION, MUSCULAR DYSGENESIS (MDG), IN THE MOUSE. I. GENETIC ANALYSIS AND GROSS MORPHOLOGY. II. DEVELOPMENTALANALYSIS
(ProQuest Dissertations & Theses, 1964) -
Developmental origins of Huntington's disease
(ProQuest Dissertations & Theses, 2017)Huntington's disease (HD) is a fatal inherited neurodegenerative disorder that is clinically characterized by movement abnormalities and psychiatric alterations appearing during midlife. The causative gene of HD, mutant ... -
Developmental regulation of sea urchin H1beta gene through phosphorylation of the embryonic transcription factor SSAP
(ProQuest Dissertations & Theses, 1999)It is a prerequisite for normal development that genes be expressed in correct temporal and spatial patterns. Sea urchins contain two families of histone genes that are differentially expressed during embryogenesis. ... -
Diastolic properties of the canine left ventricle
(ProQuest Dissertations & Theses, 1989)Left ventricular diastolic pressure-volume relations arise from a complex interplay of active decay of force (i.e. relaxation), passive elastic and viscoelastic myocardial properties, and time-varying inflow across the ... -
Differential function of Myc-family oncoproteins in proliferation and differentiation in a well-defined cell type, in vivo
(ProQuest Dissertations & Theses, 1994)Myc-family genes appear to control cellular growth, differentiation and apoptosis. This thesis has addressed whether Myc proteins regulate these processes in vivo, whether their functions are distinct or redundant, and it ... -
Differential functions of related family members Rybp and Yaf2 in cell survival
(ProQuest Dissertations & Theses, 2006)Rybp and Yaf2 are the only members of their protein family and share 71% amino acid identity. Previously, these two proteins have been shown to interact with transcription factors including YY1 and members of the E2F, Myc, ... -
DIFFERENTIATION OF MOUSE NEUROBLASTOMA CELLS
(ProQuest Dissertations & Theses, 1975) -
Direct Small Molecule BAX Inhibition as a Novel Therapeutic Strategy to Protect the Heart Against Cancer Therapies
(ProQuest Dissertations & Theses, 2018)Although advancements in chemotherapeutics have led to a dramatic increase in the number of cancer survivors, many of these patients experience unintended cardiotoxic effects as a direct result of their cancer treatments. ... -
Direct Targeting of Pro-Apoptotic BAX as a Novel Strategy for Cancer Therapy
(ProQuest Dissertations & Theses Global, 2018)Resistance to apoptosis is a hallmark of cancer. The BCL-2 protein family contains anti-and pro-apoptotic members that regulate mitochondria) apoptosis. Cancer cells ensure their survival and resistance to treatments by ... -
Directional summation in non-direction selective retinal ganglion cells
(ProQuest Dissertations & Theses, 2013)There is a severe gap in knowledge about how individual excitatory post synaptic potentials (EPSPs) are summed at the level of the retinal ganglion cell (RGC) dendrites. The terminals of bipolar cells, each with a distinct ... -
Discharge patterns of rostral pontine respiratory-modulated neurons in relation to vagal and superior laryngeal afferent input
(ProQuest Dissertations & Theses, 1990)In midcollicular decerebrate, thoracotomized, paralyzed cats, phrenic nerve discharge served as the indicator of central respiratory rhythm and was used to control ventilation by a cycle triggered respiratory pump, which ...