Cerebral malaria (CM) is the deadliest complication of Plasmodium falciparum (P. falciparum) infection. Despite extensive research, 20% of CM patients die, and of those that survive one in every four develop long-term ...

The work presented in this thesis addresses two questions relevant to central nervous system function. The first explores culture conditions that could lead to the expansion in vitro of human oligodendrocyte (OL) precursor ...

This thesis focuses on the role of cholesterol in the life cycle of the enveloped alphavirus, Semliki Forest virus (SFV). SFV infects cells via a membrane fusion reaction triggered by low pH. For fusion to occur, cholesterol ...

Small non-coding RNA known as microRNA (miRNAs) were considered to be superfluous genomic material for years. Recently, miRNAs have been shown to have regulatory roles in important cellular functions involved in carcinogenesis. ...

All mammalian cells utilize and metabolize glucose for energy production. Glucose is transported into the cell by members of the family of facilitative glucose transporters, Glut 1-6. Each glucose transporter is cell and ...

Kaposi's Sarcoma Associated Herpesvirus (KSHV) is responsible for Primary Effusion Lymphoma (PEL), Multicentric Castleman Disease and Kaposi's Sarcoma, a multifocal angioproliferative neoplasm of endothelial cells. These ...

Bacterial strains were constructed for the expression of wild type and mutant Dictyostelium actin, and were shown to accumulate the appropriately sized actin species. These strains also accumulated a truncated 29 kDa actin ...

Infection with Plasmodium falciparum can result in cerebral and placental malaria. PfEMP1 surface antigens are in large part responsible for this, and are encoded by a ∼60 member var gene family. The var family can be ...

The primary translation product of bovine preproglucagon mRNA is a precursor of 21 kDa. The molecular basis for the post-translational processing and the regulation of secretion of the precursor and the processed products ...