Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 509-528 of 1673
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Function and regulation of cyclic nucleotide phosphodiesterases
(ProQuest Dissertations & Theses, 2000)Cyclic AMP is an important second messenger involved in a variety of cellular responses to extracellular signals. Cyclic AMP phosphodiesterases (PDEs) play a role in signal transduction by hydrolyzing cellular cAMP thus ... -
Function and regulation of the WASP/WAVE family member, WAVE2, in macrophages
(ProQuest Dissertations & Theses, 2007)Cell migration is a fundamental process required for normal immune system function, embryonic development, and tissue repair. Nevertheless, this process also contributes to the pathogenesis of several diseases, such as ... -
Function and secretion of Cryptococcus neoformans virulence factors glucuronoxylomannan and laccase
(ProQuest Dissertations & Theses, 2005)Cryptococcus neoformans is an environmental yeast and the etiologic agent of cryptococcosis. This thesis is focused on the secretion and function of two C. neoformans virulence factors: capsule and laccase. CAP59 is a ... -
Function of GATA -4/5/6 genes in embryonic cardiogenesis
(ProQuest Dissertations & Theses, 1998)The GATA factors have been implicated in heart development. It is not clear at which steps of cardiogenesis GATA factors play critical roles. Each Xenopus GATA-4/5/6 gene is expressed in heart and endoderm derived tissues. ... -
FUNCTION OF INITIATION FACTOR-5 IN EUKARYOTIC INITIATION OF PROTEIN SYNTHESIS
(ProQuest Dissertations & Theses, 1986)The eukaryotic initiation of protein synthesis proceeds in several discrete steps requiring the participation of at least 10 specific protein factors as well as GTP. The first step is the binding of initiation factor, eIF-2 ... -
Function of O-fucose glycans in Notch signaling
(ProQuest Dissertations & Theses, 2010)Notch receptors are single transmembrane glycoproteins containing ∼29-36 epidermal growth factor-like (EGF) repeats in the extracellular domain. Many EGF repeats are modified with O-fucose by protein O-fucosyltransferase-1 ... -
FUNCTION OF PROTEIN FACTORS IN POLYPEPTIDE CHAIN INITIATION IN ESCHERICHIA COLI
(ProQuest Dissertations & Theses, 1978) -
Function of protein factors in polypeptide chain initiation in eukaryotes
(ProQuest Dissertations & Theses, 1992)Studies on the mechanism of initiation of protein synthesis in eukaryotic cells, particularly with regard to the functions of GTP and protein synthesis initiation factors, eIF-2, eIF-5, eIF-2B, and eIF-3 have been carried ... -
Functional analysis of caveolin tyrosine phosphorylation and the behavior of caveolin-1 (P312L), a mutant found in human breast cancers
(ProQuest Dissertations & Theses, 2002)Caveolin is a principal marker protein of caveolae, vesicular invaginations of the plasma membrane. In addition to driving the formation of membrane invaginations, several functions were proposed for caveolin in vesicular ... -
Functional analysis of the murinemdr1b promoter and its regulation by progesterone
(ProQuest Dissertations & Theses, 1993)Multidrug resistance is characterized by the cross resistance of cells to antitumor agents that are structurally and functionally unrelated. This resistance is mediated by a membrane protein, P-glycoprotein (P-gp), that ... -
Functional characterization of resistin, a novel adipokine
(ProQuest Dissertations & Theses, 2005)Adiposity is coupled to insulin action via largely unknown mechanisms. Adipocytes are the exclusive or predominant source of several secreted proteins that exert profound effects on systemic carbohydrate and lipid metabolism. ... -
Functional characterization of the novel DNA repair gene MBD4
(ProQuest Dissertations & Theses, 2004)Mbd4 (methyl-CpG binding domain 4) is a novel mammalian repair enzyme that was first identified as a member of a family of proteins containing a distinct domain that binds to methyl-CpG dinucleotides. In addition, the human ... -
Functional characterization of the nucleolar Nopp140 and Srp40 in yeast
(ProQuest Dissertations & Theses, 2003)Rat Nopp140 has been implicated to transport box C/D and H/ACA snoRNPs between the nucleolus and the Cajal body. Its yeast homolog Srp40p is localized to the nucleolus, implying that it might also be involved in ribosome ... -
Functional Characterization of the TBX/bHLH Transcription Factor MGA During Embryogenesis
(ProQuest Dissertations & Theses, 2011)This thesis analyzes the transcription factor mga during development using the zebrafish model. The mga gene encodes a unique transcription factor containing both TBOX and bHLHzip DNA-binding domains, which are both ... -
Functional classification and structural characterization of immune regulatory proteins
(ProQuest Dissertations & Theses, 2011)Proteins participate in, and are central to, many processes associated with cellular function. Among the many different roles that proteins fulfill are the catalysis of chemical reactions and the mediation of complex ... -
Functional consequences of adiponectin oligomerization state: The role of adiponectin in maintaining systemic insulin sensitivity
(ProQuest Dissertations & Theses, 2005)Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a trimer-dimer of relatively low molecular weight (LMW) and a larger multimeric structure of high molecular weight (HMW). Serum levels of ... -
Functional effects of ZBP1 in mammary and neuronal cells and tissues
(ProQuest Dissertations & Theses, 2007)RNA localization and subsequent regulation of expression occur in many cell types. This allows for variations in regional protein contents and specialization. Localization requires information in the RNA's sequence. ... -
Functional genomics approach to elucidate the role of genes implicated in cognitive function in human longevity
(ProQuest Dissertations & Theses, 2015)There is increasing evidence that longevity-associated genes protect against cognitive decline, dementia and Alzheimer's disease, suggesting common underlying physiologic pathways act at the interface of longevity and ... -
Functional Implications of REST Context Across Species and Diverse Cell Types
(ProQuest Dissertations & Theses, 2015)The RE1 silencing transcription factor (REST) recruits chromatin modifying enzymes to repressor element 1 DNA motifs. The REST complex represses genes by removing active and adding repressive histone modifications. Initially ... -
Functional interaction between estrogen and insulin -like growth factor-I in the regulation of adrenergic signaling and female reproductive function
(ProQuest Dissertations & Theses, 2001)We are interested in estradiol (E2) regulation of noradrenergic G-protein coupled receptor signal transduction in the preoptic area (POA) and hypothalamus (HYP); brain areas that govern female reproductive function. E2 ...