Browsing Albert Einstein College of Medicine: Doctoral Dissertations by Title
Now showing items 520-539 of 1673
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Functional characterization of the novel DNA repair gene MBD4
(ProQuest Dissertations & Theses, 2004)Mbd4 (methyl-CpG binding domain 4) is a novel mammalian repair enzyme that was first identified as a member of a family of proteins containing a distinct domain that binds to methyl-CpG dinucleotides. In addition, the human ... -
Functional characterization of the nucleolar Nopp140 and Srp40 in yeast
(ProQuest Dissertations & Theses, 2003)Rat Nopp140 has been implicated to transport box C/D and H/ACA snoRNPs between the nucleolus and the Cajal body. Its yeast homolog Srp40p is localized to the nucleolus, implying that it might also be involved in ribosome ... -
Functional Characterization of the TBX/bHLH Transcription Factor MGA During Embryogenesis
(ProQuest Dissertations & Theses, 2011)This thesis analyzes the transcription factor mga during development using the zebrafish model. The mga gene encodes a unique transcription factor containing both TBOX and bHLHzip DNA-binding domains, which are both ... -
Functional classification and structural characterization of immune regulatory proteins
(ProQuest Dissertations & Theses, 2011)Proteins participate in, and are central to, many processes associated with cellular function. Among the many different roles that proteins fulfill are the catalysis of chemical reactions and the mediation of complex ... -
Functional consequences of adiponectin oligomerization state: The role of adiponectin in maintaining systemic insulin sensitivity
(ProQuest Dissertations & Theses, 2005)Adiponectin is an adipocyte-specific secretory protein that circulates in serum as a trimer-dimer of relatively low molecular weight (LMW) and a larger multimeric structure of high molecular weight (HMW). Serum levels of ... -
Functional effects of ZBP1 in mammary and neuronal cells and tissues
(ProQuest Dissertations & Theses, 2007)RNA localization and subsequent regulation of expression occur in many cell types. This allows for variations in regional protein contents and specialization. Localization requires information in the RNA's sequence. ... -
Functional genomics approach to elucidate the role of genes implicated in cognitive function in human longevity
(ProQuest Dissertations & Theses, 2015)There is increasing evidence that longevity-associated genes protect against cognitive decline, dementia and Alzheimer's disease, suggesting common underlying physiologic pathways act at the interface of longevity and ... -
Functional Implications of REST Context Across Species and Diverse Cell Types
(ProQuest Dissertations & Theses, 2015)The RE1 silencing transcription factor (REST) recruits chromatin modifying enzymes to repressor element 1 DNA motifs. The REST complex represses genes by removing active and adding repressive histone modifications. Initially ... -
Functional interaction between estrogen and insulin -like growth factor-I in the regulation of adrenergic signaling and female reproductive function
(ProQuest Dissertations & Theses, 2001)We are interested in estradiol (E2) regulation of noradrenergic G-protein coupled receptor signal transduction in the preoptic area (POA) and hypothalamus (HYP); brain areas that govern female reproductive function. E2 ... -
Functional interplay of distinct ATG proteins links alpha-MSH metabolism to control of food intake
(ProQuest Dissertations & Theses, 2014)The central nervous system (CNS) is the main regulator of energy balance. In the hypothalamus, the agouti-related peptide (AgRP) neuron and the pro-opiomelanocortin (POMC) neuron that produces the anorexigenic neuropeptide ... -
Functional organization of primate cortical areas SI, SII, MI and PPC
(ProQuest Dissertations & Theses, 1998)The goals of this study were: (i) to determine whether primary somatosensory (SI), secondary somatosensory (SII) and posterior parietal (PPC) areas are initially activated in parallel or in serial, (ii) to investigate the ... -
Functional Regulation of the Histone Chaperone Nucleoplasmin
(ProQuest Dissertations & Theses, 2015)Vertebrate pre-blastula cells are transcriptionally quiescent and undergo accelerated cell replication. This unique cellular environment necessitates the use of the maternally stored proteins for replication, one of which ... -
Functional relevance of ARC in mammary gland morphogenesis and breast cancer
(ProQuest Dissertations & Theses, 2010)Cell death by apoptosis is necessary during development and in adult tissue homeostasis. Evasion of apoptosis is critical for tumorigenesis. ARC (Apoptosis Repressor with CARD Domain), an inhibitor of both the death receptor ... -
Functional spatio-temporal transcriptome analysis of enriched cell populations during postnatal mammary gland development
(ProQuest Dissertations & Theses, 2013)Postnatal development of the mammary gland is a complex, highly specialized process characterized by massive cell proliferation and tissue remodeling to ensure milk production and excretion after parturition. Many of the ... -
Functions and interactions of the carboxyl terminus of the *Myc antagonist Mxi1
(ProQuest Dissertations & Theses, 2004)The Mxi1 protein, a member of the Mad/Mxi1 sub-family of the greater Myc network, has been characterized as a Myc antagonist, transcriptional repressor, and candidate tumor suppressor protein. On the molecular level, Mxi1 ... -
Fusion glycoproteins of HIV-1 and the Ebola Virus: Structure, function, and inhibition with antibodies
(ProQuest Dissertations & Theses, 2013)There are two major topics covered in this thesis, together providing an analysis of the fusion glycoproteins of human immunodeficiency virus type-I (HIV-1) (gp41) and the Ebola Virus (GP2), class I fusion viruses. The ... -
FUSION OF UNILAMELLAR VESICLES TO PLANAR LIPID BILAYERS: A MODEL FOR EXOCYTOSIS
(ProQuest Dissertations & Theses, 1983)Exocytosis is a ubiquitous process in eukaryotic cells. Despite this, little is known about the mechanism by which this process takes place. A model system, the fusion of phospholipid vesicles with planar bilayer membranes, ... -
FV-1 MEDIATED HOST RESTRICTION OF FRIEND LEUKEMIA VIRUS
(ProQuest Dissertations & Theses, 1977) -
FV-1 MEDIATED HOST RESTRICTION OF FRIEND LEUKEMIA VIRUS
(ProQuest Dissertations & Theses, 1976) -
Gamma rhythm and its relationship with neuronal activity in early visual cortex
(ProQuest Dissertations & Theses, 2012)The gamma components (30-50 Hz) of the local field potentials (LFPs) are correlated with numerous perceptual and cognitive phenomena, and have been proposed to have important functions in sensory processing. Despite its ...