Aging is characterized by a decline in the maintenance of homeostatic processes over time that increases the risk of disease and functional decline, ultimately resulting in death. To target aging, since it is the major ...

Neural states called drives serve to stimulate essential species-specific motivated behaviors such as foraging, or mate searching. The expression of motivated behaviors occurs along a probabilistic continuum mediated by ...

In this collection of manuscripts, we use isotope effects to explore the interaction between glucose and human brain hexokinase as a model for ligand or substrate binding. Whereas such binding isotope effects have been ...

Glycophorin is the major sialoglycoprotein of the human erythrocyte membrane. While no biological role has yet been found for glycophorin in the mature erythrocyte, its presence in early precursors of the erythroid cells ...

p110beta, the catalytic subunit of P13Kbeta, is an isoform of phosphoinositide 3-kinase (PI3K), a family of lipid kinases that control critical cellular functions, including proliferation, growth, metabolism, and migration. ...

Microtubule stabilizing agents (MSAs) comprise a class of drugs that bind to microtubule (MT) polymers and stabilize them against disassembly. Several of these agents are currently in clinical use as anticancer drugs, while ...

Hemopoiesis involves a continuous process of cell proliferation and differentiation which leads to the production of functional circulatory blood cells. The proliferation and maturation of hemopoietic cells is dependent ...

Herpes simplex virus (HSV) has evolved to efficiently reorganize the host cell secretory pathway and cytoskeletal elements to achieve virus assembly and exocytosis. The assembly of viral components and the intracellular ...

In the United States, around 40,000 women are expected to die every year from breast cancer and one of eight women will develop breast cancer through their lifetime. The major reason for these deaths from cancer is due to ...

The assembly of a functional flagellum in the bacterium Caulobacter crescentus requires the protein products of approximately 30 genes expressed in temporally-discrete and spatially-distinct manner. Our current understanding ...